Conductive micropatterned polyurethane films as tissue engineering scaffolds for Schwann cells and PC12 cells

Journal of Colloid and Interface Science
Yaobin WuBaolin Guo

Abstract

Controlling cellular alignment and elongation has been demonstrated as an important parameter for developing nerve tissue engineering scaffolds. Many approaches have been developed to guide cellular orientation for nerve regeneration such as micropatterning techniques. However, most of materials used for developing micropatterning scaffolds lack of bioactivity and biofunctionability. Here we present a functional conductive micropatterned scaffold based on bioactive conductive biodegradable polyurethane prepared using a micro-molding technique. These conductive micropatterned scaffolds are able to not only induce the Schwann cells (SCs) alignment and elongation by the micropatterned surface but also enhance the nerve growth factor (NGF) gene expression of SCs by the bioactivity of these materials. Additionally, the combined effect of the bioactivity of such conductive materials and the micropatterned structure also dramatically promotes the neurite extension and elongation of PC12 cells in a highly aligned direction. These data suggest that these conductive micropatterned scaffolds that easily control cellular orientation and organization, and dramatically enhance NGF gene expression and significantly induce the neurite extensio...Continue Reading

Citations

Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hamed AmaniHamidreza Pazoki-Toroudi
Mar 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huanhuan YanPeibiao Zhang
Feb 15, 2019·Neural Regeneration Research·Antonio MerolliJoachim Kohn
Jun 30, 2019·Journal of Biomedical Materials Research. Part a·Leila LotfiShahin Bonakdar
May 21, 2020·Biofabrication·Indra ApsiteLeonid Ionov
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bushra NaureenFarina Muhamad
Oct 27, 2020·Bioactive Materials·Sophie Wendels, Luc Avérous
Feb 27, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhiqiang HuangHong Li
Apr 28, 2021·Macromolecular Rapid Communications·Wei FangYubao Li
Jun 30, 2021·Journal of Colloid and Interface Science·Weizhen SunXiubo Zhao
Dec 16, 2020·ACS Biomaterials Science & Engineering·Juan MercadoMilagros Ramos-Gómez
Aug 8, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yancheng WangDeqing Mei
Apr 24, 2018·Biomacromolecules·Baolin Guo, Peter X Ma
Jul 2, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangyun YaoCunyi Fan

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