Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology

Proceedings of the National Academy of Sciences of the United States of America
Jinghua LiJohn A Rogers

Abstract

Materials and structures that enable long-term, intimate coupling of flexible electronic devices to biological systems are critically important to the development of advanced biomedical implants for biological research and for clinical medicine. By comparison with simple interfaces based on arrays of passive electrodes, the active electronics in such systems provide powerful and sometimes essential levels of functionality; they also demand long-lived, perfect biofluid barriers to prevent corrosive degradation of the active materials and electrical damage to the adjacent tissues. Recent reports describe strategies that enable relevant capabilities in flexible electronic systems, but only for capacitively coupled interfaces. Here, we introduce schemes that exploit patterns of highly doped silicon nanomembranes chemically bonded to thin, thermally grown layers of SiO2 as leakage-free, chronically stable, conductively coupled interfaces. The results can naturally support high-performance, flexible silicon electronic systems capable of amplified sensing and active matrix multiplexing in biopotential recording and in stimulation via Faradaic charge injection. Systematic in vitro studies highlight key considerations in the materials s...Continue Reading

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Citations

Jul 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Enming SongJohn A Rogers
Jul 17, 2020·Chemical Society Reviews·Yin FangBozhi Tian
Mar 11, 2020·Micromachines·Liping XieWei Qian
May 29, 2020·Nature Materials·Enming SongJohn A Rogers
Jun 30, 2019·Nanomaterials·Dong YangShiqi Guo
Feb 9, 2021·Biosensors & Bioelectronics·Tucker StuartPhilipp Gutruf
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Weiyang YangWen Li
Dec 17, 2020·Journal of Neural Engineering·Michael TrumpisJonathan Viventi
May 22, 2021·Acta Biomaterialia·Poppy Oldroyd, George Malliaras
Jul 24, 2021·Trends in Chemistry·Yiliang LinBozhi Tian
May 30, 2021·Advanced Healthcare Materials·Mengjia ZhuYingying Zhang

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