Cone-mediated multifocal electroretinogram in age-related macular degeneration: progression over a long-term follow-up

Archives of Ophthalmology
Christina GerthJohn S Werner

Abstract

To evaluate the progression of change in the cone-driven multifocal electroretinogram (mfERG) responses in patients previously identified as having high-risk, soft drusen 63 mum or greater. Seventeen eyes of 14 patients were reevaluated after 28 to 41 months. Fundus changes were graded depending on drusen size and extent. Each of the 103 mfERG responses was analyzed and compared with age-matched normal controls and with the baseline measurement. Stable visual acuity was found in 12 of the 17 eyes. Drusen size or extent was increased, decreased, and unchanged in 6, 3, and 8 eyes, respectively. The mfERG responses demonstrated a significant progression in the response density loss and in N1 and P1 implicit time delay compared with the baseline evaluation regardless of drusen change. The extent of response deterioration occurred over the entire retinal area tested. Eyes having decreased drusen at follow-up were typically associated with higher response delays at baseline and follow-up than eyes with stable or increased drusen. Early age-related macular degeneration is associated with a progressive loss in the cone-driven mfERG response despite stable visual acuity. The response deterioration extended beyond the visible drusen area...Continue Reading

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Citations

Dec 12, 2013·Japanese Journal of Ophthalmology·Ken OginoNagahisa Yoshimura
Jun 10, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Christina Gerth
Mar 17, 2010·Documenta Ophthalmologica. Advances in Ophthalmology·Emma J BerrowJonathan M Gibson
Jan 13, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Shasha YangXing Liu
Oct 5, 2007·Journal of Neuroscience Methods·Beatrix Feigl, Andrew J Zele
Feb 20, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Beatrix FeiglBrian Brown
Apr 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K B PedersenF Møller
Feb 3, 2007·Visual Neuroscience·B FeiglP Swann
Jun 4, 2018·Investigative Ophthalmology & Visual Science·Enrico BorrelliLeonardo Mastropasqua
Nov 20, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Feng Qiu, Susan J Leat
Sep 4, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Stephen A MadillDominic H ffytche
May 13, 2020·Investigative Ophthalmology & Visual Science·Vincenzo ParisiMariacristina Parravano
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Nov 30, 2021·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Matt TrinhLisa Nivison-Smith

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