Cone-rod dysfunction in patients with unexplained reduction in visual acuity

Documenta Ophthalmologica. Advances in Ophthalmology
Y LangI Perlman

Abstract

Electrophysiologic tests were performed in 233 patients who complained of reduced visual acuity with no satisfactory clinical explanation. The functional integrity of the retina was assessed from the light- and dark-adapted electroretinogram. Macular function and conduction in the optic nerves were estimated from the flash visual evoked potentials. Of the 233 patients 78 were grouped together on the basis of the electrophysiologic and clinical findings. They were characterized by subnormal electroretinogram responses with the cone system more affected than the rod system. The flash visual evoked potential responses were of abnormal waveform and prolonged implicit times. Most of these patients exhibited normal fundi. The reduction in visual acuity, the degree of electroretinogram deficits and the pattern of the visual evoked potential responses were similar in both eyes of each patient, indicating a symmetric disorder. Slight deterioration of visual acuity and electrophysiologic variables were observed in 37 of the patients who were followed up over a period of up to 8 years. The electrophysiologic findings indicate that about 20% of patients complaining of unexplained reduction in visual acuity were suffering from a diffuse ret...Continue Reading

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Citations

Apr 30, 2003·American Journal of Ophthalmology·Jennifer A Scott, Robert A Egan
Oct 20, 1998·Progress in Retinal and Eye Research·I Perlman, R A Normann
Nov 26, 2002·The Journal of Investigative Dermatology·Margarita IndelmanEli Sprecher

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