Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling.

Investigative Ophthalmology & Visual Science
Coralie GianesiniGianluca Tosini

Abstract

Previous studies have demonstrated that melatonin has an important role in the modulation of photoreceptor viability during aging and may be involved in the pathogenesis of age-related macular degeneration.This hormone exerts its influence by binding to G-protein coupled receptors named melatonin receptor 1 (MT1) and 2 (MT2). Melatonin receptors 1 and 2 activate a wide variety of signaling pathways. Melatonin-proficient mice (C3H/f+/+) and melatonin-proficient mice lacking MT1 or MT2 receptors (MT1-/- and MT2-/-) were used in this study. Mice were killed at the ages of 3 and 18 months, and photoreceptor viability was determined by counting nuclei number in the outer nuclear layer (ONL). Cones were identified by immunohistochemistry using peanut agglutinin (PNA) and green/red and blue opsin antibodies. Protein kinase B (AKT) and forkhead box O (FOXO1) were assessed by Western blotting and immunohistochemistry. The number of nuclei in the ONL was significantly reduced in C3Hf+/+, MT1-/-, and MT2-/- mice at 18 months of age with respect to 3-month-old animals. In 18-month-old MT1-/- and MT2-/- mice, but not in C3H/f+/+, the number of cones was significantly reduced with respect to young MT1-/- and MT2-/- mice or age-matched C3H/f+...Continue Reading

Citations

Nov 15, 2019·Current Pharmaceutical Design·Luca ScuderiGianluca Scuderi
Aug 23, 2017·Cellular and Molecular Life Sciences : CMLS·Juan C MayoRafael Cernuda-Cernuda
Oct 23, 2018·Investigative Ophthalmology & Visual Science·Marie-Paule Felder-SchmittbuhlGianluca Tosini
Dec 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kenkichi BabaP Michael Iuvone
Jul 15, 2017·British Journal of Pharmacology·Erika CeconRalf Jockers
Jun 18, 2016·British Journal of Pharmacology·Ralf JockersDarius P Zlotos
Jun 27, 2018·Journal of Biological Rhythms·Kenkichi Baba, Gianluca Tosini
Apr 21, 2016·Journal of Biological Rhythms·Joseph C Besharse, Douglas G McMahon
Sep 10, 2019·Progress in Retinal and Eye Research·Daniela M VerraDavid Hicks
Jan 12, 2021·Journal of Pineal Research·Rong HuangXiaoling Liang

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BETA
AB5407

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BETA
Protein Assay

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Sigma plot

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