ConfidenHT™ System for Diagnostic Mapping of Renal Nerves

Current Hypertension Reports
Costas TsioufisDimitrios Tousoulis

Abstract

To summarize the evidence regarding the distribution of renal nerves and their patterns of anatomic variations in animal and human settings. Moreover, the methodology and results of studies regarding renal nerve stimulation (RNS) in both preclinical and clinical models are presented. There are differences regarding the number and the size of renal fibers, as well as their distance from the lumen in the diverse parts of the main renal arteries and the branches. In both animals and humans, RNS is safe and results in an increase of blood pressure (BP) while the effect on heart rate varies. In this context, the ConfidenHT™ system constitutes an integrated solution for effective RNS in humans. Due to the diversity of renal nerve anatomy in humans, arterial areas for more effective renal denervation cannot be homogenously defined. The concept of mapping of renal nerves can improve completeness of renal denervation therapies by means of integrated RNS solutions such as the ConfidenHT™ system.

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Citations

Jul 7, 2019·Current Cardiology Reports·Lucas LauderMichael Böhm
Apr 15, 2020·Nature Reviews. Cardiology·Lucas LauderFelix Mahfoud
Sep 12, 2018·Current Hypertension Reports·Raymond R Townsend, Paul A Sobotka
Nov 3, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Lucas LauderFelix Mahfoud
Jul 21, 2021·Journal of Cardiovascular Translational Research·Hao ZhouYuehui Yin

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