Confirmation and follow up of initial "NAT yields": Prospective study from a tertiary healthcare center in India

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Prashant PandeyVimarsh Raina

Abstract

In India variable rate of "NAT yield" has been demonstrated in several published reports. This study was performed with the objective to know the rate of "true NAT yield" in blood donors by confirmation with supplementary tests and follow up of initial "NAT yield" donors. A total of 48,441 blood donors were tested for HIV, HBV and HCV with enhanced chemiluminescence and ID-NAT. To know the true NAT yield status confirmation of NAT yield donors was done as with an array of serological tests, repeat ID-NAT and alternate NAT. The cumulative initial "NAT yield" rate was 1:4404 (11/48,441). Seven of 11 initial "NAT yields" were for hepatitis B whereas two each were in HIV and HCV. Among the 11 "NAT-yield" donors, eight donors were followed-up for confirmation. Out of these eight donors only 4 were found to be true HBV NAT yields. Out of four true NAT yields two were window period donations while the other two were occult hepatitis B infection with anti-HBcore total positive. Our findings suggest that all "initial NAT yields" may not be "true NAT yields". We would also like to suggest that to demonstrate the true "NAT yield" status supplementary tests and donor follow up are important to differentiate true NAT yields.

References

Nov 3, 2000·Transfusion·S L StramerD M Strong
Nov 9, 2002·Transfusion·Clive R SeedUNKNOWN Virology Subcommittee of the National Donor and Product Safety Committee, Australian Red Cross Blood Service
May 27, 2003·Clinical Chemistry·D Robert DufourBarbara Harris
Feb 26, 2004·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Michael P Busch
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ewa BrojerUNKNOWN Polish Blood Transfusion Service Viral Study Group
Jun 17, 2010·Indian Journal of Pathology & Microbiology·Dimple AroraAnshul Khetarpal
Apr 2, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·N AgarwalM Borgohain

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