PMID: 1352354Jun 1, 1992

Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate

Journal of Medical Genetics
S E HolderR M Winter

Abstract

Three RFLPs at the TGFA locus were studied in 60 unrelated British Caucasian subjects with non-syndromic cleft lip/palate and 60 controls. A highly significant association between the TaqI RFLP and the occurrence of clefting was found (chi 2 = 15.04, p = less than 0.001). No significant association was found with the two other RFLPs studied (BamHI and RsaI). Haplotypes derived from the three RFLPs at the TGFA locus also showed an over-representation of the C2A2B2 haplotype in cases compared to controls. Analyses of genotypes according to type of cleft and the presence or absence of a family history of clefting were also carried out. These results provide further support for the role of TGFA as a gene of major effect in the development of orofacial clefts in humans.

References

Sep 11, 1986·Nucleic Acids Research·J C MurrayG I Bell
Jul 10, 1987·Nucleic Acids Research·N K HaywardG I Bell
Jun 25, 1986·Nucleic Acids Research·J C MurrayG I Bell
Jan 1, 1987·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·M Tolarová
Nov 25, 1987·Nucleic Acids Research·M Jeanpierre
Jan 1, 1969·British Medical Bulletin·C O Carter

Citations

Feb 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D M Juriloff, D G Mah
May 29, 2002·Clinical Genetics·J C Murray
Jul 1, 1994·Journal of Medical Genetics·A O WilkieV A McKusick
Apr 19, 2012·Development·Heather J Ray, Lee Niswander
Jan 13, 2005·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·J S ZeigerKung-Yee Liang
Jun 30, 2004·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Maria Rita Passos-BuenoBelmino Araújo
Oct 30, 2008·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Roselinda Abdul RahmanAb Rani Samsudin
Feb 12, 2000·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Francesco CarinciMauro Tognon
Jul 27, 2000·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·F K WongS Linder-Aronson
May 23, 2002·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Natalie J Prescott, Sue Malcolm
Nov 3, 2009·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Jyotsna Murthy, Lvks Bhaskar
Jul 4, 2007·International Journal of Pediatric Otorhinolaryngology·Francesco CarinciFurio Pezzetti
Feb 26, 2004·American Journal of Medical Genetics. Part a·Lina M MorenoA C Lidral
Mar 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Laura N VandenbergMichael Levin
Jul 25, 1998·The British Journal of Oral & Maxillofacial Surgery·P A MosseyM O'Hara
Sep 26, 2000·Molecular Genetics and Metabolism·U Mittwoch
May 9, 2014·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Bo-Mi KimSeung-Hak Baek
Mar 6, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R H FinnellJ A Piedrahita
Feb 22, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·T C HartJ T Wright
Jul 31, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Michael Levin
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M C Johnston, P T Bronsky
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M C Johnston, P T Bronsky
Mar 7, 2003·The Journal of Craniofacial Surgery·Francesco CarinciMauro Tognon
Jun 24, 2004·American Journal of Medical Genetics. Part a·Dian Donnai
Dec 22, 2016·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Chen YanYang Ke-Hu
Sep 6, 2018·Genetic Testing and Molecular Biomarkers·Ebru Derelli TufekciHakki Tastan
Nov 13, 2007·The Journal of Craniofacial Surgery·Rosario RulloFrancesco Carinci
Oct 1, 1993·American Journal of Medical Genetics·R A MartinK Benirschke
Aug 1, 1993·Journal of Medical Genetics·M J Owen, P McGuffin
Sep 1, 1994·Clinical Genetics·S BeiraghiM E Hodes
Aug 20, 2003·The Journal of Clinical Pediatric Dentistry·Puneet BatraHari Parkash
Feb 19, 2004·The Journal of Clinical Pediatric Dentistry·Puneet BatraHari Parkash
Sep 1, 1996·Oral Diseases·S A Hibbert, J K Field
Nov 5, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·T H BeatyE A Wulfsberg
Jul 31, 1998·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·G M ShawE J Lammer
Sep 1, 1996·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·D F WyszynskiN E Maestri
Jan 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·P A MosseyD R Stirrups
Nov 22, 2012·American Journal of Medical Genetics. Part a·José A Velázquez-AragónAriadna González-del Angel
Jan 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·A C LidralW Magee
Oct 31, 2020·Birth Defects Research·Michael A GarlandChengji J Zhou

Related Concepts

Alleles
Cleft Lip
Cleft Palate, Isolated
Restriction Fragment Length Polymorphism
Transforming Growth Factor alpha
European Continental Ancestry Group

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.