Confirmation of Choclo virus as the cause of hantavirus cardiopulmonary syndrome and high serum antibody prevalence in Panama.

Journal of Medical Virology
Randin NelsonFrederick Koster

Abstract

Choclo virus (CHOV) was described in sigmodontine rodents, Oligoryzomys fulvescens, and humans during an outbreak of hantavirus cardiopulmonary syndrome (HCPS) in 1999-2000 in western Panama. Although HCPS is rare, hantavirus-specific serum antibody prevalence among the general population is high suggesting that CHOV may cause many mild or asymptomatic infections. The goals of this study were to confirm the role of CHOV in HCPS and in the frequently detected serum antibody and to establish the phylogenetic relationship with other New World hantaviruses. CHOV was cultured to facilitate the sequencing of the small (S) and medium (M) segments and to perform CHOV-specific serum neutralization antibody assays. Sequences of the S and M segments found a close relationship to other Oligoryzomys-borne hantaviruses in the Americas, highly conserved terminal nucleotides, and no evidence for recombination events. The maximum likelihood and maximum parsimony analyses of complete M segment nucleotide sequences indicate a close relationship to Maporal and Laguna Negra viruses, found at the base of the South American clade. In a focus neutralization assay acute and convalescent sera from six Panamanian HCPS patients neutralized CHOV in dilutio...Continue Reading

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Citations

Oct 18, 2011·Emerging Infectious Diseases·Blas ArmienFrederick Koster
Apr 4, 2012·Emerging Infectious Diseases·Mary L MilazzoCharles F Fulhorst
Aug 3, 2012·The American Journal of Tropical Medicine and Hygiene·Sonia M RaboniClaudia N Duarte dos Santos
Apr 29, 2014·Archives of Virology·William M Souza, Luiz Tadeu M Figueiredo
Mar 16, 2013·Current Opinion in Virology·John S Mackenzie, Martyn Jeggo
Jun 7, 2015·The Journal of General Virology·Paula C RiveraCristina N Gardenal
Sep 16, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Se Hun GuJin-Won Song
Jul 2, 2015·Memórias do Instituto Oswaldo Cruz·Michelly de PáduaLuiz Tadeu Moraes Figueiredo
Jan 21, 2017·Journal of Cellular Biochemistry·Sagadevan KalaiselvanGopalan Sridharan
Jan 26, 2017·Virologica Sinica·Hong JiangXuefan Bai
Nov 21, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Jonathan SchmittScott V Edwards

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