PMID: 15218418Jun 26, 2004Paper

Confirming or excluding the diagnosis of Wiskott-Aldrich syndrome in children with thrombocytopenia of an unknown etiology

Journal of Pediatric Hematology/oncology
Tadashi ArigaYukio Sakiyama

Abstract

Early diagnosis is an important factor in a better prognosis in patients with Wiskott-Aldrich syndrome (WAS), but it is not always easy to distinguish between WAS and immune thrombocytopenic purpura on clinical grounds. To confirm or to exclude a WAS diagnosis promptly for children with thrombocytopenia, the authors performed flow cytometric screening of Wiskott-Aldrich syndrome protein (WASP) for 10 children with thrombocytopenia of an unknown etiology. Five children were diagnosed with WAS, and the remaining 5 were diagnosed as having non-WAS causes of thrombocytopenia. There were no ambiguous results, and these were confirmed by genetic analysis. The authors conclude that screening by flow cytometry for WASP is recommended for boys with persistent thrombocytopenia of an unknown etiology.

References

Apr 17, 1980·The New England Journal of Medicine·L G LumR M Blaese
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Jan 1, 1995·Seminars in Thrombosis and Hemostasis·Y Najean, T Lecompte
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Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M YamadaY Sakiyama
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T ArigaY Sakiyama
Mar 6, 2002·Blood·Lucia D NotarangeloLuigi D Notarangelo
Jul 9, 2003·Journal of Pediatric Hematology/oncology·Brigitte Bader-MeunierMarie Dreyfus

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Citations

Jul 31, 2007·Clinics in Laboratory Medicine·Maurice R G O'gorman
Jun 15, 2005·Dermatologic Therapy·Nina MirchandaniNanette B Silverberg
Oct 2, 2012·Platelets·Gianmarco PoddaMarco Cattaneo
Mar 1, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Tadashi Ariga
Sep 1, 2017·Journal of Pediatric Hematology/oncology·Maria A KaralexiIoannis Petrocheilos
Aug 22, 2007·Pediatric Hematology and Oncology·A MuñozUNKNOWN Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON)
Apr 15, 2020·Journal of Pediatric Hematology/oncology·Elisa OchfeldMelanie Makhija

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