Confirming the efficacy of intravenous immunoglobulin in CIDP through minimum clinically important differences: shifting from statistical significance to clinical relevance

Journal of Neurology, Neurosurgery, and Psychiatry
Ingemar S J MerkiesC Deng

Abstract

The ICE trial demonstrated the efficacy of immune globulin intravenous (IGIV-C) over placebo in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, improving the interpretability of the results by analysing the minimum clinically important difference (MCID) had not been considered. To identify MCID thresholds of various outcome measures using different methods and to test treatment differences (IGIV-C vs placebo) using these thresholds. One anchor-based (Short Form-36 question 2) and three distribution-based (½ SD, 1 SE of measurement, and effect size) techniques were employed to identify MCID cut-offs for various impairments (electromyographic parameters, Medical Research Council (MRC) sum score, grip strength, inflammatory neuropathy cause and treatment (INCAT) sensory sum score), disability (INCAT scale score, Rotterdam handicap scale (RHS) score) and quality of life (SF-36). IGIV-C or placebo was administered every 3 weeks for up to 24 weeks to 117 CIDP patients. Patients who did not improve by ≥1 point on the INCAT scale received alternate treatment. The proportion of patients with results exceeding identified MCID thresholds was compared. Results MCID cut-offs for outcomes were determined using each...Continue Reading

Citations

Aug 16, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E K VanhoutteI S J Merkies
Jun 27, 2015·Journal of the Peripheral Nervous System : JPNS·Thomas H P DraakUNKNOWN PeriNomS study group
Jun 27, 2015·Journal of the Peripheral Nervous System : JPNS·Els K VanhoutteUNKNOWN PeriNomS Study Group
Jun 27, 2015·Journal of the Peripheral Nervous System : JPNS·Mariëlle H J PruppersUNKNOWN PeriNomS study group
Jan 1, 2013·Neuromuscular Disorders : NMD·N A M E van der BeekI S J Merkies
Sep 18, 2016·Revue neurologique·R A C Hughes, M P T Lunn
Jun 9, 2017·Journal of the Peripheral Nervous System : JPNS·Ingemar S J MerkiesUNKNOWN PRIMA trial investigators
Nov 10, 2017·Journal of the Peripheral Nervous System : JPNS·Krista KuitwaardPieter A van Doorn
Nov 16, 2016·The Cochrane Database of Systematic Reviews·Jane PritchardRuth Brassington
Feb 6, 2019·Journal of Neurology·Emanuele SpinaFiore Manganelli
Feb 23, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T H P DraakUNKNOWN PeriNomS study group
Jun 19, 2019·Journal of the Peripheral Nervous System : JPNS·Bogdan BjelicaIvana Basta
Aug 28, 2019·Neurology. Neuroimmunology and Neuroinflammation·Ari BreinerVera Bril
May 30, 2020·Journal of the Peripheral Nervous System : JPNS·Pietro Emiliano DonedduEduardo Nobile-Orazio
Sep 3, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K KuitwaardP A van Doorn
Apr 23, 2020·Muscle & Nerve·Pietro E Doneddu, Robert D M Hadden
Sep 2, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Pietro Emiliano DonedduUNKNOWN Italian CIDP Database study group
Sep 4, 2012·Current Opinion in Neurology·Ingemar S J MerkiesCatharina G Faber
Sep 4, 2015·Journal of the Peripheral Nervous System : JPNS·Els K VanhoutteUNKNOWN PeriNomS Study Group
Jun 22, 2012·The New England Journal of Medicine·Brian J Dlouhy, Rajesh C Rao
Nov 20, 2019·Journal of Clinical Neuromuscular Disease·Ali Asghar OkhovatFarzad Fatehi
Sep 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G LiberatoreUNKNOWN Italian CIDP Database Study Group
Feb 18, 2021·Neurology·Jeffrey A AllenRichard A Lewis
Apr 9, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ivo BozovicIvana Basta
Jun 27, 2021·Journal of Neurology·S R M BusUNKNOWN ICOS Consortium
Jul 31, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Peter Y K Van den BerghHaluk A Topaloglu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.