PMID: 9176832Jun 1, 1997Paper

Conflicting indicators of biotin status from a cross-sectional study of normal pregnancy

Journal of the American College of Nutrition
D M Mock, D D Stadler

Abstract

To assess biotin nutritional status during normal human gestation. Urine samples were obtained in a cross-sectional design from 16 women in early pregnancy (17 +/- 1 weeks, mean +/- 1 SD) and from 13 women in late pregnancy (36 +/- 1 weeks). The urinary excretion of biotin, two metabolites bisnorbiotin (BNB) and biotin sulfoxide (BSO), and the organic acid 3-hydroxyisovaleric acid (3-HIA) were measured by HPLC/avidin-binding assay and GC/MS, respectively. Excretion rates were expressed as concentration ratios to urinary creatinine. In both early and late pregnancy, 3-HIA excretion was increased compared to controls (p < 0.0001), suggesting decreased activity of a biotin-dependent enzyme caused by tissue biotin depletion. In early pregnancy, urinary excretion of biotin was normal; in late pregnancy, excretion was increased (p < 0.0002), suggesting biotin status was not decreased. In late pregnancy, urinary excretion of BNB and BSO were increased (p < 0.009). The apparent conflict in the indices of biotin status is not explained by this study but could be resolved by two alternate explanations: 1) Pregnancy caused an impairment of renal reclamation of biotin, BNB, and BSO leading to a paradoxical increase in biotin excretion 2) P...Continue Reading

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Citations

Dec 3, 2002·Archives of Medical Research·Diana Pacheco-AlvarezAlfonso León Del Río
Nov 13, 2004·The Journal of Nutritional Biochemistry·J Zempleni, D M Mock
Jan 11, 2013·The British Journal of Nutrition·Wei Kay EngJanos Zempleni
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·J Zempleni, D M Mock
Oct 15, 2010·The American Journal of Clinical Nutrition·Shawna L StrattonDonald M Mock
Aug 21, 2008·Nutrition Reviews·Janos ZempleniSubhashinee S K Wijeratne
Sep 4, 2009·Expert Review of Endocrinology & Metabolism·Janos ZempleniSubhashinee Sk Wijeratne
Jun 23, 2009·Steroids·Armida Báez-SaldañaCristina Fernandez-Mejia
Aug 30, 2008·Nutrition·Toshiaki WatanabeToru Fukui
Mar 26, 2009·BioFactors·Janos ZempleniYousef I Hassan
Jun 11, 2002·Annual Review of Nutrition·Robert J McMahon
Jan 1, 2013·Nutrition and Metabolic Insights·Katsumi ShibataTsutomu Fukuwatari
Jan 9, 2008·The British Journal of Nutrition·Mari Watanabe-KamiyamaMichio Komai
Aug 15, 2014·The Journal of Nutrition·Cydne A PerryMarie A Caudill
Mar 30, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David W Lawson, Monique Borgerhoff Mulder
Mar 22, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·J Mark Ruscin
Aug 4, 1998·The American Journal of Physiology·J Zempleni, D M Mock
Jan 30, 2002·The American Journal of Clinical Nutrition·Donald M MockNell I Mock
Jan 30, 2002·The American Journal of Clinical Nutrition·Hamid M Said
Jul 31, 2003·The Journal of Nutrition·Donald M MockDeborah K Hansen
Aug 10, 2006·The American Journal of Clinical Nutrition·Shawna L StrattonDonald M Mock
Mar 13, 1999·The American Journal of Clinical Nutrition·H M Said
Mar 4, 1999·The Journal of Nutrition·D M Mock

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