Confocal and dermoscopic features of basal cell carcinoma in Gorlin-Goltz syndrome: A case report

The Australasian Journal of Dermatology
Alice CasariCaterina Longo

Abstract

Gorlin-Goltz (GS) syndrome is an autosomal dominant disease linked to a mutation in the PTCH gene. Major criteria include the onset of multiple basal cell carcinoma (BCC), keratocystic odontogenic tumours in the jaws and bifid ribs. Dermoscopy and reflectance confocal microscopy represent imaging tools that are able to increase the diagnostic accuracy of skin cancer in a totally noninvasive manner, without performing punch biopsies. Here we present a case of a young woman in whom the combined approach of dermoscopy and RCM led to the identification of multiple small inconspicuous lesions as BCC and thus to the diagnosis of GS syndrome.

References

Jun 15, 1970·Zeitschrift für Haut- und Geschlechtskrankheiten·M Ryckeboer, H Zaun
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Mar 1, 1980·Journal of the American Academy of Dermatology·J B Howell, R G Freeman
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May 5, 1960·The New England Journal of Medicine·R J GORLIN, R W GOLTZ
Dec 8, 2004·Journal of the American Academy of Dermatology·Sarita NoriSalvador González
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Jun 15, 2014·Journal of the American Academy of Dermatology·Caterina LongoGiovanni Pellacani

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Citations

Apr 11, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C LongoG Pellacani
Oct 16, 2021·Pediatric Dermatology·Randy F KoJohn R Durkin

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