Confocal chromoscopic endomicroscopy is superior to chromoscopy alone for the detection and characterisation of intraepithelial neoplasia in chronic ulcerative colitis

Gut
D P HurlstoneS S Cross

Abstract

The diagnosis of intraepithelial neoplasia is pivotal for ongoing clinical management decisions in ulcerative colitis. Previous studies have compared the diagnostic yield of endomicroscopy with conventional "white light" endoscopy and hence the overall objective increase of endomicroscopy targeted biopsies as compared to chromoscopy guided alone is not apparent. We performed a prospective randomised controlled study to compare the diagnostic yield of intraepithelial neoplasia and cancer in patients undergoing ulcerative colitis screening using chromoscopy assisted endomicroscopy (group A) versus pan-colonic chromoscopy assisted colonoscopy (group B). Patients were randomised in a 1:1 ratio to undergo screening colonoscopy using either chromoscopic endomicroscopy or chromoscopy alone with targeted biopsies. Circumscribed lesions were characterised using endomicroscopy and chromoscopy with pit pattern analysis. Targeted biopsies in addition to conventional 10 cm quadrantic biopsies were taken. Primary outcome addressed the number of intraepithelial neoplasias detected in each group. Endomicroscopy targeted biopsies significantly increased the yield of intraepithelial neoplasia as compared to pan-chromoscopy and biopsy alone (p<0....Continue Reading

Associated Clinical Trials

Apr 16, 2008·Annette Weissmann

Citations

Oct 24, 2008·Inflammatory Bowel Diseases·Thomas UllmanFrancis A Farraye
Jun 8, 2011·Inflammatory Bowel Diseases·Virginia FuscoMarianne Ortner
Nov 6, 2009·International Journal of Colorectal Disease·Thomas Borschitz, Ralf Kiesslich
Feb 1, 2011·International Journal of Colorectal Disease·Ute GüntherChristian Bojarski
Dec 15, 2012·Clinical and Translational Gastroenterology·Jean-Francois TurcotteJulia J Liu
Dec 10, 2013·Diseases of the Colon and Rectum·Howard RossUNKNOWN Standards Practice Task Force of the American Society of Colon and Rectal Surgeons
Jan 6, 2009·Current Opinion in Gastroenterology·Kerry Dunbar, Marcia Canto
Jun 19, 2008·Journal of Gastroenterology and Hepatology·Lesley-Ann SmithDavid P Hurlstone
Feb 9, 2010·Journal of Gastroenterology and Hepatology·Rupert W L LeongAndrew V Biankin
May 25, 2010·Journal of Gastroenterology and Hepatology·Rui JiCheng-Jun Zhou
Jul 9, 2008·World Journal of Gastroenterology : WJG·Peter-Laszlo Lakatos, Laszlo Lakatos
Sep 28, 2010·World Journal of Gastroenterology : WJG·Hugh James Freeman
Jan 11, 2011·World Journal of Gastroenterology : WJG·Dan Ionuţ GheoneaAdrian Săftoiu
Aug 10, 2012·World Journal of Gastroenterology : WJG·Jessica K Dyson, Matthew D Rutter
Jan 1, 2011·Case Reports in Gastrointestinal Medicine·Giorgio DiamantisGiorgio Battaglia
Dec 3, 2014·Gastrointestinal Endoscopy·UNKNOWN ASGE Technology Committee
Aug 28, 2010·Journal of Gastroenterology·Matthew D Rutter
Sep 17, 2013·World Journal of Gastroenterology : WJG·Giovanni Domenico De Palma, Antonio Rispo
Apr 17, 2016·Clinical Colorectal Cancer·Fornaro RosarioEnzo Andorno
Nov 26, 2015·Journal of Digestive Diseases·Shishira BharadwajRoger Charles
Feb 3, 2016·Current Treatment Options in Gastroenterology·Anna M Buchner, Gary R Lichtenstein
Nov 21, 2012·Annales de pathologie·Jean-François Mosnier
Nov 1, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Barbara BradenRoger W Chapman
Sep 18, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kiyoshi ShibuyaIchiro Yoshino
Jul 15, 2009·Gastrointestinal Endoscopy·Martin GoetzRalf Kiesslich
Jun 30, 2009·Gastrointestinal Endoscopy·Sergey V KantsevoyWilliam M Tierney
Mar 3, 2009·Gastrointestinal Endoscopy·Geoffrey C NguyenThemistocles Dassopoulos
Oct 14, 2008·Gastroenterology·Rupert W L LeongAndrew V Biankin
Sep 16, 2008·Best Practice & Research. Clinical Gastroenterology·Ralf KiesslichMarkus F Neurath
Aug 5, 2008·Gastrointestinal Endoscopy Clinics of North America·Ralf KiesslichMarkus F Neurath
Dec 17, 2014·Clinical Endoscopy·Song I Bae, You Sun Kim
Dec 17, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·J A LouwersR H M Verheijen
Apr 28, 2010·Gastroenterology·Michael B Wallace, Ralf Kiesslich
Jun 6, 2013·Gastrointestinal Endoscopy Clinics of North America·Steven Naymagon, James F Marion
Aug 13, 2013·Gastroenterology Clinics of North America·Martin Goetz
Nov 13, 2007·Gastroenterology Clinics of North America·Noam Harpaz
Oct 5, 2010·Gastrointestinal Endoscopy Clinics of North America·Robert S Bresalier
Aug 11, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David P HurlstoneMichael D Hunter
Nov 15, 2012·Gastrointestinal Endoscopy·Mikihiro Fujiya, Yutaka Kohgo
Nov 18, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C TrovatoC Crosta
Sep 16, 2008·Best Practice & Research. Clinical Gastroenterology·Anna M Buchner, Michael B Wallace
Sep 3, 2013·Parasitology International·Naoki HosoeToshifumi Hibi
Mar 7, 2014·Journal of Microscopy·M GuH Kang

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