Confocal microscopy and optical coherence tomography imaging of hereditary granular dystrophy

Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association
Kristine DaltonLyndon Jones

Abstract

This case report examines the clinical characteristics of hereditary granular dystrophy through the use of slit lamp digital photography, confocal microscopy (CM) and optical coherence tomography (OCT). A review of the literature describing the histopathological and genetic associations of stromal dystrophies, suggest it may be possible to differentiate dystrophies based on their clinical manifestations, and appearances of CM and OCT images, with or without the use of genetic testing. Two sisters, previously diagnosed with Granular (Groenouw I) Dystrophy, were examined. Examination included the use of digital slit lamp photography, CM and OCT imaging. "Breadcrumb" opacities were visualized in the anterior two-thirds of the stroma with all three imaging techniques. Opacities were demonstrated in the posterior third of the stroma with the digital photography and OCT techniques. The digital photography, CM and OCT images support the sister's diagnosis of Granular (Groenouw I) Dystrophy. Currently, genetic and histopathological testing are the only techniques available to determine exactly which corneal dystrophy and gene mutation are present. The results of this case report demonstrate that slit lamp digital photography, combined ...Continue Reading

References

Jan 1, 1988·Cornea·E S MalbranJ O Croxatto
Sep 1, 1971·American Journal of Ophthalmology·S Akiya, S I Brown
Oct 1, 1993·Klinische Monatsblätter für Augenheilkunde·B SeitzG O Naumann
Jan 1, 1994·Nature Genetics·E M StoneL M Streb
Sep 4, 1998·American Journal of Ophthalmology·M OkadaY Tano
Aug 25, 1999·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A G ChiouH E Kaufman
Sep 15, 1999·Ophthalmology·L P WernerG Renard
Dec 28, 1999·American Journal of Ophthalmology·G K Klintworth
Aug 12, 2000·Optometry and Vision Science : Official Publication of the American Academy of Optometry·P Hrynchak, T Simpson
Mar 27, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·T D Williams, W M Lyle
Oct 24, 2002·European Journal of Biochemistry·Clair-Florent Schmitt-BernardAngel Argilés
Sep 30, 2003·Optics Letters·Maciej WojtkowskiAndrzej Kowalczyk
Oct 15, 2003·Archives of Ophthalmology·Akira KobayashiYohko Amaya-Ohkura
Apr 16, 2004·Cornea·Carsten H Meyer, Walter Sekundo
Aug 10, 2005·Archives of Ophthalmology·Chitra KannabiranMeena Lakshmipathi
Dec 7, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·D SuesskindK U Loeffler
Sep 12, 2007·Archives of Ophthalmology·Akira KobayashiKazuhisa Sugiyama
Sep 26, 2007·Cornea·Leonardo N SantosMiguel N Burnier
Jan 25, 2008·Seminars in Ophthalmology·Vasilliki Poulaki, Kathryn Colby
Jul 25, 2008·Cornea·Bartlomiej J KaluznyMaciej Wojtkowski
Sep 11, 2008·The Ocular Surface·Trefford Simpson, Desmond Fonn

❮ Previous
Next ❯

Citations

Jan 15, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·David P Roncone
Oct 31, 2013·Seminars in Ophthalmology·George D KymionisIoannis G Pallikaris
Nov 21, 2012·Seminars in Ophthalmology·Anita N ShuklaPedram Hamrah
Oct 25, 2016·The Ocular Surface·Andrea CruzatPedram Hamrah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.