PMID: 15223803Jun 30, 2004Paper

Confocal scanning laser ophthalmoscopy classifiers and stereophotograph evaluation for prediction of visual field abnormalities in glaucoma-suspect eyes

Investigative Ophthalmology & Visual Science
Christopher BowdRobert N Weinreb

Abstract

To determine whether Heidelberg Retina Tomograph (HRT; Heidelberg Engineering, Dossenheim, Germany) classification techniques and investigational support vector machine (SVM) analyses can detect optic disc abnormalities in glaucoma-suspect eyes before the development of visual field abnormalities. Glaucoma-suspect eyes (n = 226) were classified as converts or nonconverts based on the development of repeatable (either two or three consecutive) standard automated perimetry (SAP)-detected abnormalities over the course of the study (mean follow-up, approximately 4.5 years). Hazard ratios for development of SAP abnormalities were calculated based on baseline classification results, follow-up time, and end point status (convert, nonconvert). Classification techniques applied were HRT classification (HRTC), Moorfields Regression Analysis, forward-selection optimized SVM (SVM fwd) and backward elimination-optimized SVM (SVM back) analysis of HRT data, and stereophotograph assessment. Univariate analyses indicated that all classification techniques were predictors of the development of two repeatable abnormal SAP results, with hazards ratios (95% confidence interval [CI]) ranging from 1.32 (1.00-1.75) for HRTC to 2.0 (1.48-2.76) for ste...Continue Reading

Associated Clinical Trials

Sep 22, 2005·Linda Zangwill

References

Mar 5, 1998·The British Journal of Ophthalmology·D F Garway-HeathR A Hitchings
Aug 26, 1998·Ophthalmology·G WollsteinR A Hitchings
May 27, 2003·Investigative Ophthalmology & Visual Science·James C H Tan, Roger A Hitchings
Jun 26, 2007·Seminars in Ophthalmology·L M ZangwillR N Weinreb

❮ Previous
Next ❯

Citations

Sep 16, 2008·Eye·R A Hitchings
Feb 3, 2005·Photomedicine and Laser Surgery
Mar 23, 2005·Photomedicine and Laser Surgery
Feb 16, 2007·Current Opinion in Ophthalmology·Amish Doshi, Kuldev Singh
Jan 7, 2010·Journal of Glaucoma·Paolo BrusiniMaria Letizia Salvetat
Jun 4, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Christopher Bowd, Michael H Goldbaum
Apr 11, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Zach NadlerJoel S Schuman
Nov 26, 2010·Journal of Biomaterials Science. Polymer Edition·Kazunari HigaShigeto Shimmura
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Christopher BowdMichael H Goldbaum
Jun 5, 2012·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Allison K UngarJoel S Schuman
Dec 17, 2008·Survey of Ophthalmology·Pooja SharmaJoel S Schuman
Nov 30, 2007·American Journal of Ophthalmology·Javier Moreno-MontañésAngeles Sebastián
Oct 3, 2007·Ophthalmology·Shan C LinUNKNOWN Ophthalmic Technology Assessment Committee Glaucoma Panel
Aug 29, 2006·American Journal of Ophthalmology·Yaniv BarkanaRobert Ritch
Oct 3, 2006·American Journal of Ophthalmology·Maziar LalezaryLinda M Zangwill
Jul 18, 2018·Ophthalmic Epidemiology·Geetha SrinivasanRamanjit Sihota
Dec 19, 2018·Current Opinion in Ophthalmology·Chengjie ZhengMichael V Boland
Oct 24, 2019·The British Journal of Ophthalmology·Sripad Krishna DevallaMichael J A Girard
Jun 13, 2015·The Open Ophthalmology Journal·Jessica S MaslinSyril K Dorairaj
Dec 2, 2005·Applied Optics·Olivier Karim NaounAnne-Marie Benoit
Jul 10, 2021·Annual Review of Vision Science·Alexi GeevargheseJoel S Schuman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.