PMID: 698289Sep 4, 1978Paper

Conformation of snake toxic polypeptides studied by a method of prediction and circular dichroism

Biochimie
A MénezP Fromageot

Abstract

Short and long neurotoxins as well as cardiotoxins belong to three distinct families of homologous toxic polypeptides extracted from cobra venoms. A study of their conformation was undertaken by using the method of Chou and Fasman for prediction of secondary structures of proteins. To improve the reliability of this method, an averaging scheme was developed. The data obtained showed that all toxins have a predominant trend for beta-sheet nucleation. Moreover, predicted beta-sheet strands fitted well those actually observed from X-ray data. Thus, it seems that all toxins share similarities in their secondary structure. This proposition was supported by a comparative study of the CD spectra of a set of toxins. Nevertheless, the present data suggest also that each type of toxins possesses localized structural individualities which might be responsible for the biological and/or immunological specificities.

References

Oct 1, 1977·The Biochemical Journal·N Maeda, N Tamiya
Sep 28, 1976·Biochimica Et Biophysica Acta·D P Botes, C C Viljoen
Jan 1, 1977·Biopolymers·J W SnowJ A Schellman
May 3, 1977·Biochemistry·Y H ChenJ T Yang
Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·Y IshikawaN Tamiya
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B W LowJ S Richardson
Dec 1, 1975·Hoppe-Seyler's Zeitschrift für physiologische Chemie·F J Joubert
Dec 1, 1975·Hoppe-Seyler's Zeitschrift für physiologische Chemie·F J Joubert
Jan 1, 1974·Toxicon : Official Journal of the International Society on Toxinology·C C Yang
Oct 1, 1973·FEBS Letters·E V GrishinV M Sorokin

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Citations

Jan 1, 1987·Journal of Molecular Evolution·R Breckenridge, M J Dufton
Jan 1, 1979·Toxicon : Official Journal of the International Society on Toxinology·T Abe, N Tamiya
Jan 1, 1980·Toxicon : Official Journal of the International Society on Toxinology·F J Joubert, N Taljaard
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·A MenezP Fromageot
Jan 1, 1985·Pharmacology & Therapeutics·A Ménez
Jan 1, 1988·Pharmacology & Therapeutics·M J Dufton, R C Hider
Jun 1, 1979·Biophysical Journal·P Y Chou, G D Fasman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M D WalkinshawA Maelicke
Mar 1, 1988·European Journal of Biochemistry·J M GrognetR C Hider
Apr 14, 1980·Biochemical and Biophysical Research Communications·C ThiéryJ M Thiéry
Sep 2, 1980·Biochemistry·A MénezP Fromageot
Apr 1, 1980·European Journal of Biochemistry·A F DrakeR C Hider
Jan 1, 1980·CRC Critical Reviews in Biochemistry·C Toniolo
Jan 1, 1983·CRC Critical Reviews in Biochemistry·M J Dufton, R C Hider
Jan 24, 1998·Journal of Biomolecular Structure & Dynamics·T K KumarC Yu

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