PMID: 698197Sep 5, 1978Paper

Conformation of the mushroom toxin beta-amanitin in the crystalline state

Biochemistry
E C KostansekW E Thiessen

Abstract

A single crystal X-ray diffraction analysis of beta-amanitin, a bicyclic octapeptide toxin isolated from the poisonous mushroom Amanita phalloides, shows that the molecule has distinct regions of hydrophilic and hydrophobic residues and two 18-membered rings. The study confirms the proposed chemical sequence and the configuration of the residues. All eight peptide groups are in the trans conformation. Four intramolecular hydrogen bonds, two strong and two weak, occur in the structure. The toxin cocrystallizes with seven water and three ethanol molecules and participates in an extensive hydrogen-bonding network. The crystal structure was solved by direct methods. The space group is P2(1)2(1)2(1), and unit cell dimensions are a = 14.004(3), b = 14.943(3), and c = 30.794(7) A.

References

Feb 16, 1977·Journal of the American Chemical Society·E C KostansekW E Thiessen
Dec 1, 1974·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H Faulstich, M Weckauf-Bloching
Jun 27, 1974·Biochimica Et Biophysica Acta·M Cochet-Meilhac, P Chambon
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Apr 14, 1971·Nature: New Biology·W L Bell, R H Barth
Jan 1, 1968·Justus Liebigs Annalen der Chemie·H Faulstich, T Wieland
May 1, 1969·Toxicon : Official Journal of the International Society on Toxinology·C Cessi, L Fiume
May 28, 1969·Journal of Molecular Biology·K L CarrawayD E Koshland

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Citations

Jan 1, 1996·Biopolymers·M Marraud, A Aubry
Mar 20, 1995·Molecular & General Genetics : MGG·M S Bartolomei, J L Corden
Jan 1, 1980·CRC Critical Reviews in Biochemistry·C Toniolo
Aug 1, 1982·Biochemical and Biophysical Research Communications·A BavosoV Muri-Valle
Jun 5, 2015·Chembiochem : a European Journal of Chemical Biology·Liang ZhaoDavid M Perrin
Jun 19, 2019·Angewandte Chemie·Mihajlo TodorovicDavid M Perrin
Mar 1, 1990·International Journal of Peptide and Protein Research·G ZanottiE Trivellone
Feb 25, 2020·Angewandte Chemie·Christian LutzChristoph Müller
Nov 1, 1991·International Journal of Peptide and Protein Research·J E MullersmanJ F Preston
Apr 1, 1983·International Journal of Peptide and Protein Research·E Falck-PedersenD L Venton
Sep 1, 1983·International Journal of Peptide and Protein Research·T Wieland
Nov 1, 1983·International Journal of Peptide and Protein Research·P W Morris, R McSwine
Mar 22, 2018·Journal of the American Chemical Society·Kaveh MatinkhooDavid M Perrin

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