Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle

Biochemical Pharmacology
C P Bianchi

Abstract

The ryanodine receptor (RyR) and the dihydropyridine (DHP) receptor (L-channels) comprise the main elements of the functional feet of the triadic element in skeletal muscle. These two main elements have conformational states that are regulated by the membrane potential and the consequent electrical field. The pharmacological action of ryanodine on skeletal muscle depends upon the physiological functional state of the RyR. At a resting potential of -90 m V, ryanodine at very low concentrations, 10(-11) M, causes the RyR to have a low conductance state which allows calcium to leak from the terminal cisternae of the sarcoplasmic reticulum and to be recycled with ATP utilization, leading to a marked increase in oxygen consumption and aerobic metabolism. At concentrations greater than 10(-6) M, ryanodine can cause a slowly developing contracture of resting muscle, inhibit the muscle twitch when the RyR complex is formed during stimulation, and, if formed before stimulation, accelerate the development of contracture. Biochemical studies have revealed that the RyR has four binding sites in which the conductance state depends upon the number of sites occupied by ryanodine. Our present understanding of the RyR-operated calcium channel i...Continue Reading

References

Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·C P Bianchi, S Narayan
Jan 1, 1990·Life Sciences·C P Bianchi
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S FleischerE A Fleer
Apr 1, 1966·Journal of Cellular Physiology·A S Fairhurst, D J Jenden
May 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·A S FAIRHURST, D J JENDEN
Jun 1, 1963·Journal of Cellular and Comparative Physiology·C P BIANCHI

❮ Previous
Next ❯

Citations

Jun 20, 2001·Acta Physiologica Scandinavica·G O SkeieN E Gilhus
Mar 19, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Matteo OttoliniSwapnil K Sonkusare
Jan 22, 2014·The European Journal of Neuroscience·Jennifer S Ignatious RajaC Giovanni Galizia
Mar 19, 2014·The Journal of General Physiology·Seine A ShintaniNorio Fukuda
May 28, 2014·The Journal of General Physiology·James M McNallyJosé R Lemos
Sep 25, 2019·Biomolecules·Louise Conrard, Donatienne Tyteca
Jul 14, 2017·Journal of Cell Science·Agnese De MarioMaria Catia Sorgato
Apr 27, 2016·The Journal of General Physiology·Liang XiaoHéctor H Valdivia
Nov 11, 2017·The Journal of General Physiology·Gerhard Meissner
Nov 29, 2002·The Journal of Physiology·Christopher R L Simkus, Christian Stricker
May 5, 2005·The Journal of Clinical Endocrinology and Metabolism·Kaushik MaitiJae Young Seong
Oct 1, 2003·British Journal of Pharmacology·Elena SanzAngel Luis Garcia-Villalón
Aug 26, 1998·Biochimica Et Biophysica Acta·A Szewczyk, S Pikuła

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Annals of the New York Academy of Sciences
E J Dropcho
Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
B PanikkarC P Sharma
© 2021 Meta ULC. All rights reserved