PMID: 9538505Apr 16, 1998Paper

Conformational analysis of amphotericin B--cholesterol channel complex

The Journal of Membrane Biology
A Silberstein

Abstract

A molecular model of ionic channel formed by flexible molecules of amphotericin B and cholesterol is proposed. Complexes with axial symmetry from 5 to 11 were simulated. In contrast to the model of the channel formed from rigid molecules, flexible molecules form a tightly packed structure consolidated by both dispersive forces and intermolecular hydrogen bonds. Contributions of a lactone ring, polar heads, cholesterol and lipid environments to the global energy of the complex formation are discussed. Among the complexes capable of ionic transport, that of axial symmetry eight is preferable. Two types of complexes, differing by the number of intramolecular hydrogen bonds, are shown to be possible.

Citations

Aug 15, 2002·Biochimica Et Biophysica Acta·Shigeru Matsuoka, Michio Murata
May 31, 2013·Journal of the American Chemical Society·Brandon C WilcockMartin D Burke
Nov 24, 2012·Nature Chemistry·Brandon C WilcockMartin D Burke
Dec 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meysam MobasheriMahmoud Reza Jaafari
Feb 24, 2009·Biophysical Chemistry·Mariusz BaranJan Mazerski
Feb 17, 2007·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Maciej BaginskiKamil Sternal
Jun 26, 2021·European Journal of Medicinal Chemistry·Ojasvi GuptaVikramdeep Monga

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