PMID: 6170311Aug 4, 1981Paper

Conformational aspects critical to the immunospecificity of the type III group B streptococcal polysaccharide

Biochemistry
Harold J JenningsDennis Kasper

Abstract

Immunization of rabbits with group B type III streptococcus organisms induces two distinct populations of antibodies with a specificity for determinants on the native capsular polysaccharide antigen of these organisms. Some of the structural and conformational features of the two determinants responsible for the formation of these antibodies were elucidated by (13)C NMR and serological studies on the native type III polysaccharide and some of its structurally modified analogues. The specificity of the determinant corresponding to the major population of antibodies is dependent of the presence of sialic acid residues on the native type III antigen, and although these residues are not an integral part of the determinant, they exert conformational control over it. The carboxylate groups of the sialic acid residues are an important factor in this control mechanism which could possibly involve intramolecular hydrogen bonding. The terminal sialic acid residues control the orientation of the penultimate beta-d-galactopyranose residues with respect to the backbone of the native antigen. The orientation of these residues is critical to the determinant because the determinant is probably small and is located precisely at the junction of ...Continue Reading

References

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Feb 1, 1979·The Journal of Experimental Medicine·D L KasperH J Jennings
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Mar 31, 1934·The Journal of Experimental Medicine·R C Lancefield

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Citations

Jun 30, 1995·Journal of Chromatography. a·L C Paoletti, K D Johnson
Apr 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hilde-Kari GuttormsenDennis L Kasper
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C E RubensD L Kasper
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M R WesselsD L Kasper
Apr 23, 2005·Infection and Immunity·Michael J CieslewiczCraig E Rubens
Jan 1, 1985·Journal of Clinical Pathology·P De PaoliG Santini
Jul 1, 1983·The Journal of Clinical Investigation·D L KasperH J Jennings
Nov 1, 1990·The Journal of Clinical Investigation·M R WesselsH J Jennings
Nov 15, 1996·The Journal of Clinical Investigation·D L KasperC J Baker
May 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Renuka KadirvelrajRobert J Woods
Nov 1, 1990·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·R RateiH Hahn
Nov 3, 1988·The New England Journal of Medicine·C J BakerD L Kasper
Apr 27, 2016·Infection and Immunity·Guillaume Goyette-DesjardinsMariela Segura
Jul 6, 2014·The Journal of Biological Chemistry·Francesco BertiImmaculada Margarit
Aug 9, 2006·Clinical and Vaccine Immunology : CVI·Francis MichonPeter C Fusco
Feb 15, 2020·Chemistry : a European Journal·Davide OldriniRoberto Adamo
Jun 3, 2015·Glycobiology·Omid Haji-GhassemiStephen V Evans
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cinzia ColomboLuigi Lay
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Filippo CarboniFrancesco Berti
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca StingeleArthur O Tzianabos
Mar 16, 2019·Microbiology Spectrum·Lawrence C Paoletti, Dennis L Kasper

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