Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450

Biochimica Et Biophysica Acta
Tomas LaursenBirger Lindberg Møller

Abstract

The NADPH-dependent cytochrome P450 reductase (CPR) is a key electron donor to eucaryotic cytochromes P450 (CYPs). CPR shuttles electrons from NADPH through the FAD and FMN-coenzymes into the iron of the prosthetic heme-group of the CYP. In the course of these electron transfer reactions, CPR undergoes large conformational changes. This mini-review discusses the new evidence provided for such conformational changes involving a combination of a "swinging" and "rotating" model and highlights the molecular mechanisms by which formation of these conformations are controlled and thereby enables CPR to serve as an effective electron transferring "nano-machine".

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K McMillanB S Masters
Jun 1, 1992·Archives of Biochemistry and Biophysics·M DrouxR Douce
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T D Porter, C B Kasper
Jan 1, 1993·Annual Review of Biophysics and Biomolecular Structure·L N Johnson, D Barford
Apr 16, 1996·Biochemical and Biophysical Research Communications·M Ingelman-SundbergF P Guengerich
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·M WangJ J Kim
Oct 17, 1998·Journal of Structural Biology·T H BayburtS G Sligar
Feb 27, 1999·Protein Science : a Publication of the Protein Society·Q ZhaoH P Driessen
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·I F SevrioukovaT L Poulos
Dec 22, 1999·Journal of Molecular Biology·N BlomS Brunak
Apr 5, 2001·Trends in Plant Science·R DouceF Rébeillé
May 24, 2001·The Journal of Biological Chemistry·P A HubbardJ J Kim
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Timothy H Bayburt, Stephen G Sligar
May 7, 2003·Current Opinion in Biotechnology·Marc MorantDanièle Werck-Reichhart
Jul 9, 2003·Biochemistry·Emmanuelle GracietBrigitte Gontero
Jan 5, 2005·Comptes rendus biologies·Michel ThellierCamille Ripoll
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Charlotte KristensenSøren Bak
Feb 24, 2005·Annual Review of Plant Biology·Brenda S J Winkel
Apr 30, 2005·Current Opinion in Plant Biology·Kirsten JørgensenBirger Lindberg Møller
Aug 30, 2005·Biochemical and Biophysical Research Communications·Takashi Iyanagi
Sep 15, 2005·The New Phytologist·Lee J Sweetlove, Alisdair R Fernie
Sep 16, 2005·Journal of Computer-aided Molecular Design·Eszter HazaiDavid Kupfer
Dec 31, 2005·Nucleic Acids Research·Samuel FloresMark Gerstein
Sep 12, 2006·Biochimica Et Biophysica Acta·Irina BrandinaRobert P Martin
Sep 19, 2006·Biochimica Et Biophysica Acta·Frank HannemannRita Bernhardt
Aug 21, 2007·Phytochemistry·Kirsten Annette NielsenBirger Lindberg Møller

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Citations

Apr 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciJulia Winkelmann
Jun 5, 2012·The Journal of Biological Chemistry·Thanawat PhongsakPimchai Chaiyen
Jan 18, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tessa MosesAlain Goossens
Feb 9, 2016·Molecular Phylogenetics and Evolution·Trine Bundgaard AndersenHenrik Toft Simonsen
Nov 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krutika Bavishi, Nikos S Hatzakis
Jul 9, 2013·Protein Science : a Publication of the Protein Society·Axel Sündermann, Chris Oostenbrink
Jul 15, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Nicolas BertramMarité Cárdenas
Sep 12, 2014·Archives of Toxicology·Marie StiborováHeinz H Schmeiser
Dec 2, 2014·Trends in Plant Science·Tomas LaursenJean-Etienne Bassard
Nov 4, 2016·The Journal of Physical Chemistry. B·Veronika NavrátilováMichal Otyepka
Oct 18, 2016·Biotechnology and Bioengineering·Dario Vazquez-AlbaceteMorten H H Nørholm
Oct 11, 2016·Physical Chemistry Chemical Physics : PCCP·Petr JeřábekVáclav Martínek
Apr 17, 2013·Biotechnology and Applied Biochemistry·Tomas LaursenBirger Lindberg Møller
Oct 17, 2018·Natural Product Reports·Camilla KnudsenTomas Laursen
Jan 1, 2016·The Journal of Biological Chemistry·D Fernando EstradaEmily E Scott
Aug 15, 2012·The Journal of Biological Chemistry·Maria WadsäterMarité Cárdenas
Mar 24, 2018·Molecular Medicine Reports·Yunyi YaoXianhong Li
Dec 29, 2019·Scientific Reports·Ana C EbrechtDiederik J Opperman
Nov 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jessica CaciollaSilvia Gobbi
Jan 28, 2021·International Journal of Molecular Sciences·Manuel SellnerMartin Smieško
Jan 28, 2020·The Journal of Physical Chemistry Letters·Ida RitaccoAlessandra Magistrato
Apr 17, 2021·Nature Communications·Simon Bo JensenNikos S Hatzakis

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