PMID: 37340Jun 1, 1979

Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines

Journal of Medicinal Chemistry
A BalsamoR Ceserani

Abstract

A series of 1-(p-nitrophenyl)-2-aminoethanol derivatives and their morpholine analogues have been synthesized and pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl-substituted compounds. In agreement with the previously obtained results, the weak alpha-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of the structure-activity relationships of alpha-adrenergic drugs.

Related Concepts

Derivatives
Structure-Activity Relationship
Smooth Muscle
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists
Norepinephrine
Ethanolamine
Norepinephrine Measurement
Drug Interactions
Ethanolamines

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