PMID: 5591Apr 1, 1976

Conformational populations for antihistamines and antihypertensives in solution

Journal of Pharmaceutical Sciences
N S Ham


The conformations in aqueous solution were determined for the XCH2CH2N systems of some antihistamines (H1-receptor antagonists) and some adrenergic neuron blocking agents, including the antihypertensive drugs guanethidine and guanoclor. The rotameric species thought to be the pharmacologically active one is often not the only rotamer present in solution.


Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Apr 1, 1970·The Journal of Pharmacy and Pharmacology·A F Casy, R R Ison
Nov 1, 1971·Journal of Pharmaceutical Sciences·N S Ham
Apr 21, 1972·Nature·J W BlackE M Parsons
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A MakriyannisH G Mautner
May 1, 1973·Journal of Medicinal Chemistry·N S HamR R Ison
May 1, 1967·Journal of Medicinal Chemistry·J AugsteinG J Tiddy


Dec 28, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Matsue Ebitani, Toshiaki Ebitani

Related Concepts

Antihypertensive Agents
Guanethidine Sulfate (2: 1), 14C-Labeled
Antihistamines, Classical
Structure-Activity Relationship
Sympatholytic Effect

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