PMID: 5591Apr 1, 1976

Conformational populations for antihistamines and antihypertensives in solution

Journal of Pharmaceutical Sciences
N S Ham

Abstract

The conformations in aqueous solution were determined for the XCH2CH2N systems of some antihistamines (H1-receptor antagonists) and some adrenergic neuron blocking agents, including the antihypertensive drugs guanethidine and guanoclor. The rotameric species thought to be the pharmacologically active one is often not the only rotamer present in solution.

References

Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Apr 1, 1970·The Journal of Pharmacy and Pharmacology·A F Casy, R R Ison
Nov 1, 1971·Journal of Pharmaceutical Sciences·N S Ham
Apr 21, 1972·Nature·J W BlackE M Parsons
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A MakriyannisH G Mautner
May 1, 1973·Journal of Medicinal Chemistry·N S HamR R Ison
May 1, 1967·Journal of Medicinal Chemistry·J AugsteinG J Tiddy

Citations

Dec 28, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Matsue Ebitani, Toshiaki Ebitani

Related Concepts

Antihypertensive Agents
Dimedrol
Guanethidine Sulfate (2: 1), 14C-Labeled
Guanidines
Antihistamines, Classical
Thionylan
Kriptin
Structure-Activity Relationship
Sympatholytic Effect
Azaron

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2021 Meta ULC. All rights reserved