PMID: 6106638Apr 1, 1980Paper

Conformational studies of somatostatin and selected analogues by Raman spectroscopy

International Journal of Peptide and Protein Research
S L HanH A Scheraga

Abstract

Laser Raman spectroscopy has been used to study the conformations of somatostatin and some selected analogues in aqueous solution. The results indicate that the CS-SC dihedral angles of somatostatin and of these analogues (except [Ala3,14]-SS, which has no disulfide bond) are within 20 degrees of +/- 85 degrees, and the SS-CC dihedral angles are predominantly in the range of 50 degrees-180 degrees. Furthermore, from the behavior of the amide I' and amide III bands, it appears that somatostatin adopts a beta-pleated sheet structure, whereas its analogues are less ordered (to varying degrees).

References

Jan 1, 1977·Annual Review of Physiology·W ValeM Brown
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R K ScheuleH A Scheraga
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D F VeberR Hirschmann
Sep 1, 1978·Metabolism: Clinical and Experimental·W ValeM Brown
Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·H E Van Wart, H A Scheraga
Jan 1, 1976·Annual Review of Medicine·R Guillemin, J E Gerich
Aug 25, 1977·Biochimica Et Biophysica Acta·L A HoltF H Stewart
Nov 1, 1977·Biochemistry·L A HolladayD Puett
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Holladay, D Puett
Jul 22, 1975·Biochemical and Biophysical Research Communications·J RivierW Vale
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R BurgusR Guillemin
May 1, 1974·Journal of the American Chemical Society·J E Rivier
Jan 1, 1973·Biopolymers·T J YuW L Peticolas
Jul 1, 1966·Photochemistry and Photobiology·S GurnaniK T Augusti
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J Bandekar, S Krimm

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Citations

Jan 1, 1982·CRC Critical Reviews in Biochemistry·T L BlundellS P Wood
Mar 1, 1982·Peptides·J W FoxJ M Stewart

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