PMID: 1201907Jan 1, 1975Paper

Conformational studies on sequential polypeptides Part VI. Structural investigations on (Pro-Leu-Gly)10, (Pro-Leu-Gly)n and (Leu-Pro-Gly)n

International Journal of Peptide and Protein Research
A ScatturinE Bordignon

Abstract

The conformational properties of (Pro-Leu-Gly)10, (Pro-Leu-Gly)n and (Leu-Pro-Gly)n were investigated both in solution and in solid state. By circular dichroism studies it was possible to demonstrate the formation of an ordered collagen-like structure for (Pro-Leu-Gly)n in hexafluroisopropanol-water mixtures and in ethylene glycol; (Leu-Pro-Gly)n assumes an ordered conformation only in ethylene glycol; (Pro-Leu-Gly)10 is unordered under all the conditions studied. X-ray diffraction patterns indicated that (Pro-Leu-Gly)n and (Leu-Pro-Gly)n assume a triple helical structure in solid state. In addition, the investigation of (Pro-Leu-Gly)n strongly suggests that this type of structure is a single chain triple helix. The X-ray patterns of (Pro-Leu-Gly)10 do not allow us to ascertain a collagen or polyproline II-like structure for this decatripeptide.

Citations

Feb 1, 1987·International Journal of Peptide and Protein Research·V GuantieriD Vasilescu
Sep 1, 1987·International Journal of Peptide and Protein Research·I Z SiemionM Rospenk
Dec 1, 1992·Journal of Biomolecular Structure & Dynamics·A M TamburroD D Gordini
Jul 1, 1977·Biopolymers·H J GorenR M Epand
Aug 15, 1998·Biopolymers·M GoodmanE Locardi
May 1, 1981·International Journal of Peptide and Protein Research·W Roth, E Heidemann
Dec 1, 1984·International Journal of Peptide and Protein Research·A M TamburroD Vasilescu
Jan 1, 1978·International Journal of Peptide and Protein Research·M Bansal, G N Ramachandran
Jan 1, 1977·International Journal of Peptide and Protein Research·M Bansal

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