Conformational transition of poly(alpha-L-glutamic acid). A polyelectrolytic approach.

Biophysical Chemistry
S PaolettiJ C Benegas

Abstract

The charge-induced conformational transition of poly(alpha-L-glutamic acid) (PLGA) is considered in this paper from the point of view of proton dissociation. Equations for the excess electrostatic Gibbs energy of dissociation (i.e., delta pKa) are derived as a function of the degree of ionization, alpha. These analytical equations are used to describe some experimental dissociation curves at different polymer and salt concentrations. The dependence of the calculated delta pKa with respect to the ionic strength for the two conformational states, alpha-helical and extended coil, respectively, is rather satisfactorily explained. Even more interesting are the predictions which are derived from this approach for the transition point, alpha tr which is found to be ionic-strength dependent, in full agreement with the experimental results.

Citations

May 10, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Lukás PalivecKarel Volka
Sep 10, 2009·The Journal of Physical Chemistry. B·Ivan DonatiSergio Paoletti
Jan 1, 1991·Biophysical Chemistry·A CesàroJ C Benegas
Nov 18, 2005·Journal of Colloid and Interface Science·Achilles Tsortos, George H Nancollas
Apr 1, 1990·International Journal of Biological Macromolecules·A CesàroR Urbani
Jul 21, 2006·The Journal of Physical Chemistry. B·Andrej Godec, Joze Skerjanc

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