PMID: 8951087Oct 1, 1996Paper

Conformational transmission in ATP synthase during catalysis: search for large structural changes

Journal of Bioenergetics and Biomembranes
M Futai, H Omote

Abstract

Escherichia coli ATP synthase has eight subunits and functions through transmission of conformational changes between subunits. Defective mutation at beta Gly-149 was suppressed by the second mutations at the outer surface of the beta subunit, indicating that the defect by the first mutation was suppressed by the second mutation through long range conformation transmission. Extensive mutant/pseudorevertant studies revealed that beta/alpha and beta/gamma subunits interactions are important for the energy coupling between catalysis and H+ translocation. In addition, long range interaction between amino and carboxyl terminal regions of the gamma subunit has a critical role(s) for energy coupling. These results suggest that the dynamic conformation change and its transmission are essential for ATP synthase.

References

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Citations

Jan 1, 1997·Annual Review of Biochemistry·P D Boyer
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M A BianchetL M Amzel
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·S Kawasaki-NishiM Forgac
Oct 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kazuaki NishioMasamitsu Futai
May 1, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masamitsu FutaiYoh Wada
Jan 5, 2000·The Journal of Biological Chemistry·E VasilyevaM Forgac
Apr 18, 1998·The Journal of Biological Chemistry·X H LengM Forgac
Feb 7, 1998·The Journal of Biological Chemistry·K J MacLeodM Forgac
Mar 22, 2003·The Journal of Biological Chemistry·Ya SuFiona E Karet
Sep 3, 1998·The Journal of Biological Chemistry·E Vasilyeva, M Forgac
Jan 5, 2000·The Journal of Biological Chemistry·T HirataM Futai
Dec 6, 1997·Biochemical and Biophysical Research Communications·Y Kagawa, T Hamamoto
Jun 6, 2000·Biochimica Et Biophysica Acta·W D Frasch
Aug 27, 1999·Advances in Biophysics·Y Kagawa

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