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Conformationally restricted analogs of histamine H1 receptor antagonists: trans and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine

Journal of Medicinal Chemistry

Jan 1, 1976

Aamir AhmedVernon Grund

PMID: 1535

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Abstract

The syntheses of trans- and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine (1 and 2) are described. Compounds 1 and 2 were found to be inhibitors to histamine, acetylcholine, and barium chloride induced contractions of the isolated guinea pig ileum. Compounds 1 and 2 do not exhibit app...read more

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Acetylcholine Measurement
Barium
Analogs & derivatives
Histamine N-Methyltransferase
Smooth Muscle
Histamine Measurement
Histamine H1 Receptor Antagonists [MoA]
Acetylcholine Sulfate (1: 1)
Entire Ileum
Analog
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  • Conformationally restricted analogs of histamine H1 receptor antagonists: trans and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine

    Journal of Medicinal Chemistry

    Jan 1, 1976

    Aamir AhmedVernon Grund

    PMID: 1535

    DOI:

    Abstract

    The syntheses of trans- and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine (1 and 2) are described. Compounds 1 and 2 were found to be inhibitors to histamine, acetylcholine, and barium chloride induced contractions of the isolated guinea pig ileum. Compounds 1 and 2 do not exhibit app...read more

    Mentioned in this Paper

    Acetylcholine Measurement
    Barium
    Analogs & derivatives
    Histamine N-Methyltransferase
    Smooth Muscle

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