Conformationally switchable water-soluble fluorescent bischolate foldamers as membrane-curvature sensors

Langmuir : the ACS Journal of Surfaces and Colloids
Roshan W Gunasekara, Yan Zhao

Abstract

Membrane curvature is an important parameter in biological processes such as cellular movement, division, and vesicle fusion and budding. Traditionally, only proteins and protein-derived peptides have been used as sensors for membrane curvature. Three water-soluble bischolate foldamers were synthesized, all labeled with an environmentally sensitive fluorophore to report their binding with lipid membranes. The orientation and ionic nature of the fluorescent label were found to be particularly important in their performance as membrane-curvature sensors. The bischolate with an NBD group in the hydrophilic α-face of the cholate outperformed the other two analogues as a membrane-curvature sensor and responded additionally to the lipid composition including the amounts of cholesterol and anionic lipids in the membranes.

References

Oct 19, 1979·Biochimica Et Biophysica Acta·F OlsonD Papahadjopoulos
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·S WalkerD Kahne
Jan 11, 2001·Organic Letters·U TaotafaP B Savage
Dec 13, 2001·Chemical Reviews·D J HillJ S Moore
Jan 25, 2003·Annual Review of Biophysics and Biomolecular Structure·Michael Edidin
Dec 3, 2003·Science·Brian J PeterHarvey T McMahon
Dec 16, 2003·Angewandte Chemie·Wolfgang H BinderFredric M Menger
May 14, 2004·Annual Review of Biophysics and Biomolecular Structure·Kai Simons, Winchil L C Vaz
Jul 30, 2005·Nature Reviews. Drug Discovery·Markus R Wenk
Dec 2, 2005·Nature·Harvey T McMahon, Jennifer L Gallop
Dec 15, 2005·Journal of the American Chemical Society·Yan Zhao, Zhenqi Zhong
Jan 4, 2007·Journal of the American Chemical Society·Yan ZhaoEui-Hyun Ryu
Jan 16, 2007·Nature Structural & Molecular Biology·Guillaume DrinBruno Antonny
Dec 17, 2008·The Journal of Organic Chemistry·Yan Zhao
Apr 22, 2009·Cell·Adam FrostPietro De Camilli
Sep 15, 2009·Nature Chemical Biology·Nikos S HatzakisDimitrios Stamou
Jun 25, 2010·Journal of the American Chemical Society·Hongkwan Cho, Yan Zhao
Jul 20, 2010·Trends in Biochemical Sciences·Michael M KozlovLeonid V Chernomordik
Dec 15, 2010·Journal of the American Chemical Society·Hongkwan ChoYan Zhao
Jan 12, 2011·Annual Review of Physical Chemistry·Tobias BaumgartSovan L Das
Mar 29, 2011·Annual Review of Biochemistry·Bruno Antonny
Mar 31, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Hongkwan Cho, Yan Zhao
Sep 22, 2011·Chemistry : a European Journal·Shiyong Zhang, Yan Zhao
Oct 19, 2012·ACS Chemical Biology·Leslie A MortonHang Yin
Mar 30, 2013·Accounts of Chemical Research·Yan ZhaoShiyong Zhang
Dec 23, 2014·Journal of the American Chemical Society·Roshan W Gunasekara, Yan Zhao

❮ Previous
Next ❯

Citations

Apr 16, 2016·Chemical Communications : Chem Comm·Sunil KumarAndrew D Miranker
Apr 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriele MichelettiCarla Boga
Nov 30, 2018·Journal of Chemical Theory and Computation·Sibali DebnathKrishnan Raghavachari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.