PMID: 8610183Apr 2, 1996Paper

Conformations and folding of lysozyme ions in vacuo

Proceedings of the National Academy of Sciences of the United States of America
D S GrossE R Williams

Abstract

Proton transfer reactivity of isolated charge states of the protein hen egg-white lysozyme shows that multiple distinct conformations of this protein are stable in the gas phase. The reactivities of the 9+ and 10+ charge state ions, formed by electrospray ionization of "native" (disulfide-intact) and "denatured" (disulfide-reduced) solutions, are consistent with values calculated for ions in their crystal structure and fully denatured conformations, respectively. Charge states below 8+ of both forms, formed by proton stripping, have similar or indistinguishable reactivities, indicating that the disulfide-reduced ions fold in the gas phase to a more compact conformation.

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Citations

Aug 1, 1996·Journal of Mass Spectrometry : JMS·E R Williams
Mar 1, 1997·Mass Spectrometry Reviews·M K Green, C B Lebrilla
Dec 14, 2004·Chemistry : a European Journal·M Isabel CatalinaAlbert J R Heck
Sep 6, 2007·Analytical and Bioanalytical Chemistry·E D RaczyńskaM Szelag
Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Harry J SterlingEvan R Williams
Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Russell E BornscheinBrandon T Ruotolo
Sep 21, 2012·Journal of the American Society for Mass Spectrometry·Roberto MarcheseSimone Raugei
Nov 1, 1995·Journal of the American Society for Mass Spectrometry·P D SchnierE R Williams
Sep 1, 1996·Journal of the American Society for Mass Spectrometry·P D SchnierE R Williams
Dec 4, 2003·Journal of the American Society for Mass Spectrometry·John C JurchenEvan R Williams
Oct 7, 2004·Journal of the American Society for Mass Spectrometry·John C JurchenEvan R Williams
May 26, 2005·Journal of the American Society for Mass Spectrometry·Joseph A LooIgor V Chernushevich
May 26, 2005·Journal of the American Society for Mass Spectrometry·Richard L WongDavid E Clemmer
Jul 19, 2005·Journal of the American Society for Mass Spectrometry·Errol W Robinson, Evan R Williams
Aug 8, 2006·Journal of the American Society for Mass Spectrometry·Errol W RobinsonEvan R Williams
Nov 7, 2006·Journal of the American Society for Mass Spectrometry·Stormy L Koeniger, David E Clemmer
Feb 16, 2008·Journal of the American Society for Mass Spectrometry·David TouboulRenato Zenobi
Dec 17, 2009·Journal of the American Society for Mass Spectrometry·Alireza FattahiTouradj Solouki
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May 22, 2002·Journal of the American Society for Mass Spectrometry·Stephen J Valentine, David E Clemmer
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Jul 1, 2009·Nature Chemistry·David E Clemmer, Stephen J Valentine
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kathrin BreukerFred W McLafferty

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