Abstract
Conformations of cysteine disulfides were analyzed in X-ray, nuclear magnetic resonance (NMR), and co-crystal structures of peptide toxins retrieved from Protein Data Bank. The parameters side chain torsional angles, disulfide strain energy, interatomic Cα/Cβ distances, and Ramachandran angles were used as probes to derive conformational features of cysteine disulfides. Schmidt, Ho, and Hogg ( 2006 ) Allosteric disulfide bonds. Biochemistry, 45, 7429-7433 scheme was adapted to classify the disulfide conformations of peptide toxins. Anomalies were observed while treating "forward" and "reverse" asymmetric disulfide conformers as same disulfide conformation in peptide toxins. Thus, new scheme was proposed to classify "forward" and "reverse" asymmetric disulfide conformers separately. Total available conformers space for classification of toxins disulfides is 32. Interestingly, all 32 disulfide conformations are observed in peptide toxins. -LHSpiral is predominant disulfide conformation of peptide toxins. Significant variations were observed in population of occurrence of disulfide conformers, disulfide strain energy, and distribution of DCα-Cα and DCβ-Cβ values between X-ray, NMR, and co-crystal structures of peptide toxins. The ...Continue Reading
References
Nov 1, 1978·Antimicrobial Agents and Chemotherapy·R D WilliamsH D Mercer
Aug 1, 1990·International Journal of Peptide and Protein Research·N SrinivasanP Balaram
Jul 1, 1985·European Journal of Biochemistry·S NishidaN Tamiya
Jan 1, 1981·Advances in Protein Chemistry·J S Richardson
Sep 15, 1981·Journal of Molecular Biology·J M Thornton
Jan 2, 1993·FEBS Letters·A BeckerW D Schleuning
Dec 6, 1996·Journal of Molecular Biology·P M Harrison, M J Sternberg
Jun 10, 1998·Journal of Molecular Biology·J GehrmannD J Craik
Oct 29, 2000·Acta Crystallographica. Section D, Biological Crystallography·G KrygerJ L Sussman
Feb 19, 2003·Biochemical and Biophysical Research Communications·Adriano M C PimentaMarie France Martin-Eauclaire
Dec 17, 2003·The Biochemical Journal·Stéphanie MouhatJean-Marc Sabatier
Jan 13, 2004·Physiological Reviews·Heinrich Terlau, Baldomero M Olivera
Apr 29, 2004·Chemistry & Biology·Elizebeth C TurnerRudolf K Allemann
Mar 26, 2005·The EMBO Journal·Yves BournePascale Marchot
Jun 1, 2005·Biochemistry·Gloria P CorpuzBaldomero M Olivera
Jun 14, 2005·Nature Structural & Molecular Biology·Patrick H N CelieAugust B Smit
Nov 10, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M RichardsonM N Cordeiro
Jun 14, 2006·Biochemistry·Bryan SchmidtPhilip J Hogg
Jul 21, 2007·BMC Structural Biology·Bryan Schmidt, Philip J Hogg
Jun 2, 2009·Current Biology : CB·Craig S WalkerAndres V Maricq
Jun 16, 2009·Journal of Structural Biology·Olga A Ozhogina, Emile L Bominaar
Nov 26, 2009·Toxicon : Official Journal of the International Society on Toxinology·Ricardo C Rodríguez de la VegaLourival D Possani
Dec 24, 2009·Public Understanding of Science·Monika Kurath, Priska Gisler
Apr 8, 2010·Expert Review of Molecular Diagnostics·Harald Kolmar
Sep 17, 2010·Analytical Chemistry·Kallol GuptaPadmanabhan Balaram
Sep 21, 2010·Journal of Theoretical Biology·José Rui Ferreira MarquesAndré Melo
Oct 13, 2012·Toxicon : Official Journal of the International Society on Toxinology·Ryan J R McCleary, R Manjunatha Kini
Dec 12, 2012·Trends in Ecology & Evolution·Nicholas R CasewellBryan G Fry
Mar 26, 2013·Cellular and Molecular Life Sciences : CMLS·Jennifer J SmithPaul F Alewood
Aug 13, 2013·Proteins·Neha V KalmankarP Balaram
Aug 12, 2014·Science·Lei ChenEric Gouaux
Feb 20, 2015·Cellular and Molecular Life Sciences : CMLS·T A ReeksP F Alewood
Dec 19, 2015·The Journal of Biological Chemistry·Gilles MourierDenis Servent
Apr 4, 2017·Computational Biology and Chemistry·Panchada Ch V GovinduKonkallu Hanumae Gowd