Confronting the challenge: individualized immune monitoring after organ transplantation using the cellular immune function assay

Clinica Chimica Acta; International Journal of Clinical Chemistry
Moshe IsraeliMichael Oellerich

Abstract

The survival of a transplanted organ is dependent on avoidance of rejection, achieved through continuous immuno-suppression. Management of the transplant recipient confronts the clinician with a key challenge of post-transplant immune monitoring. Early detection of an activated allo-immune response is a harbinger of incipient rejection. Thus, timely intervention may prevent acute and chronic injury to the transplanted organ. Similarly, over immune-suppression can lead to infections or malignancies, hence the importance of early detection of the precarious suppression. The need for non-invasive systemic immune monitoring of the transplant recipient is therefore imperative. This review describes the cellular immune function assay--a non-invasive diagnostic method for evaluation of the net state of the recipient's cellular immune function. We describe the background that brought about the need for a reliable diagnostic tool for serial immune monitoring, and we overview the main mile-stones in the assimilation of the assay and its implementation in the clinic. The arising conclusion presents a novel non-invasive diagnostic bio-marker for post-transplant immune monitoring which enables the clinician to intervene prior to manifestati...Continue Reading

References

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Aug 3, 2011·Journal of Cancer Research and Clinical Oncology·Jian-Wen ChengJian Zhou

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Citations

Jan 26, 2013·Stem Cells Translational Medicine·Andrea Loewendorf, Marie Csete
Sep 30, 2015·Therapeutic Drug Monitoring·Maria ShipkovaEberhard Wieland
Mar 1, 2019·Therapeutic Drug Monitoring·Millán OlgaBrunet Mercè
Mar 19, 2019·Therapeutic Drug Monitoring·Olga MillánMercè Brunet
Oct 10, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qian-Qian ZhangSheng Chang

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