Confusional arousals during non-rapid eye movement sleep: evidence from intracerebral recordings

Sleep
Mathilde FlamandWilliam Szurhaj

Abstract

Confusional arousals (CA) are characterized by the association of behavioral awakening with persistent slow-wave electroencephalographic (EEG) activity during non-rapid eye movement (NREM) sleep-suggesting that sensorimotor areas are "awake" while non-sensorimotor areas are still "asleep." In the present work, we aimed to study the precise temporo-spatial dynamics of EEG changes in cortical areas during CA using intracerebral recordings. Nineteen episodes of CA were selected in five drug-resistant epileptic patients suffering incidentally from arousal disorders. Spectral power of EEG signal recorded in 30 non-lesioned, non-epileptogenic cortical areas and thalamus was compared between CA and baseline slow-wave sleep. Clear sequential modifications in EEG activity were observed in almost all studied areas. In the last few seconds before behavior onset, an increase in delta activity occurred predominantly in frontal regions. Behavioral arousal was associated with an increase of signal power in the whole studied frequency band in the frontal lobes, cingulate cortex, insular cortex, and precuneus. Afterwards, a diffuse cessation of very low frequencies (<1 Hz) occurred. Simultaneously, a hypersynchronous delta activity (HSDA) (1-1....Continue Reading

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Citations

Sep 11, 2020·Journal of Sleep Research·Anna CastelnovoMaria Paola Canevini
Jan 27, 2021·Clocks & Sleep·Greta MainieriFederica Provini
Jun 12, 2021·Nature and Science of Sleep·Milena CamaioniLuigi De Gennaro
Jul 4, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Yoko SuzukiTakashi Abe

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