Congenic mapping of the MHC-linked susceptibility to type 1 diabetes in the NOD mouse: at least two genes contribute to the Idd16 effect

Annals of the New York Academy of Sciences
Yoshihisa HiromineH Ikegami

Abstract

Major histocompatibility complex (MHC)-linked susceptibility to type 1 diabetes consists of multiple components. Previous studies with NOD mice congenic for the MHC from a sister strain, the CTS mouse, mapped Idd16, a second component of MHC-linked susceptibility to type 1 diabetes, in the region adjacent to, but distinct from Idd1 in the class II region. In this study, three lines of subcongenic strains were established from the original congenic strain. Phenotypic analysis of the strains indicated that MHC-linked susceptibility to type 1 diabetes consists of at least three components: Idd1, Idd16.2 adjacent to Idd1, and Idd16.1 telomeric to Idd16.2.

References

Apr 30, 1993·Biochemical and Biophysical Research Communications·H IkegamiT Ogihara
Jun 1, 1996·Current Opinion in Genetics & Development·C JulierG M Lathrop
Dec 1, 1996·Endocrine Journal·H Ikegami, T Ogihara

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Citations

Feb 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary A YuiJeffrey A Longmate

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