Congenic mapping of type 1 diabetes--protective gene(s) in an interval of 4 Mb on rat chromosome 6q32

Biochemical and Biophysical Research Communications
Nora Klöting, Ingrid Klöting

Abstract

Congenic BB.SHR rats introgressing a segment of SHR chromosome 6 onto BB/OK background showed a reduction of diabetes frequency by 72% compared with BB/OK. To identify underlying gene(s), the introgressed segment was shortened and the expression of seven genes (Yy1, Dlk1/Pref-1, Wd40 repeat, Cdc42, Rtl1, Traf3, and Tnfaip2) was studied in blood and spleen of non-diabetic BB/OK, BB.6S, and SHR males and females at an age of 30, 70, and 90 days. The phenotype of congenic sublines narrowed the diabetes-protective region to 4 Mb. The relative expression of Yy1 and Pref-1 in blood and of Pref-1 in spleen was significantly reduced by 50-90% in male and female BB.6S and SHR compared with BB/OK favouring Yy1 and Pref-1 as candidate genes. All other genes were differently expressed according to gender and strain.

References

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Jul 6, 2004·Molecular Genetics and Metabolism·Nora Klöting, Ingrid Klöting

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Citations

May 29, 2012·Genes & Nutrition·Jörn LangeNiels Follak
Feb 1, 2011·Transplant Immunology·Jeanette BahrNiels Follak
Dec 19, 2006·Diabetes/metabolism Research and Reviews·Nora KlötingIngrid Klöting
Mar 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Peng GaoKai Tan

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