PMID: 3760383Nov 1, 1986Paper

Congenital abnormalities of the conduction system in sudden death in young adults

Journal of the American College of Cardiology
S Bharati, M Lev

Abstract

The sudden death of four apparently healthy young people, three men aged 25, 24 and 21 years, respectively, and one woman aged 20 years, was investigated. The heart was of normal size in two and was slightly enlarged in two. The conduction system in all hearts was serially sectioned. In all hearts the His bundle showed loop formation. In two, the branching bundle was left-sided with the right bundle branch intramyocardial. In the other two, the His bundle was markedly fragmented. Two had myocarditis, and three had arteriolosclerosis of the summit of the ventricular septum. These findings suggest the following: autopsy may be otherwise normal or show minimal findings in cases of sudden death in young people, with significant abnormalities seen only in the conduction system. The common denominator in the conduction system may be a congenital abnormality of the His bundle (in two hearts it was fragmented, in two it was left-sided and there was loop formation in all). Acquired changes may be present, such as arteriolosclerosis of the summit of the ventricular septum (three cases), myocarditis (two cases), and fatty infiltration in the atria (all four cases), a congenital abnormality of the His bundle with or without other findings ...Continue Reading

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Citations

Nov 7, 2003·International Journal of Cardiology·Giulia OttavianiThomas N James
Jul 1, 1991·Journal of the American College of Cardiology·S BharatiM Lev
Dec 1, 1987·Journal of the American College of Cardiology·L Rossi
Dec 19, 1998·Journal of the American College of Cardiology·M P Suarez-Mier, C Gamallo
Sep 16, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·L MatturriL Rossi
Dec 11, 2002·Journal of Internal Medicine·A WistenT Messner
Sep 12, 2003·The New England Journal of Medicine·Barry J Maron
Jun 1, 1997·The American Journal of Forensic Medicine and Pathology·J W StumppW Bär
Apr 1, 1994·Journal of Cardiovascular Electrophysiology·S Bharati, M Lev
Dec 3, 1988·BMJ : British Medical Journal·A C ThomasM J Davies
Sep 5, 1992·BMJ : British Medical Journal·M J Davies
May 1, 1996·Cardiology Clinics·B J Maron
Nov 15, 1991·The American Journal of Cardiology·Y DroryM R Kramer
Dec 14, 2004·The Journal of International Medical Research·M TurkmenY Basaran
May 1, 1993·Circulation·S N WillichJ E Muller
Jan 13, 2015·Journal of Cardiovascular Medicine·Marzia VassaliniFrancesco De Ferrari
Oct 23, 1997·Clinics in Sports Medicine·J D MillsP D Thompson

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