PMID: 6166287Aug 1, 1981Paper

Congenital absence of pain

Archives of Neurology
M ManfrediL Medolago

Abstract

A 16-year-old boy had congenital absence of pain sensitivity and no impairment of other sensory modalities. Routine electrophysiologic investigation showed no abnormalities. The threshold and latency of electrically elicited corneal reflex and cortical potentials evoked by tooth pulp stimulation were normal, but suprathreshold electric stimulation of corneal mucosa and dental pulp, as well as electric stimulation of dorsal roots, did not elicit pain. The total CSF opioid activity was raised. However, naloxone hydrochloride administration failed to reverse the analgesia. The axon reflex to intradermal injection of histamine dihydrochloride was absent. Cutaneous nerve branches showed unspecific changes affecting part of unmyelinated axons. most of the unmyelinated as well as the myelinated axons were normal. We consider the case an example of congenital indifference to pain.

Citations

Jan 13, 2009·Der Nervenarzt·S Lanz, C Maihöfner
Aug 23, 2007·Cyberpsychology & Behavior : the Impact of the Internet, Multimedia and Virtual Reality on Behavior and Society·Jeffrey I GoldDavid A Thomas
Nov 18, 2008·Expert Opinion on Investigational Drugs·Steve England
Jun 16, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Florian T NickelChristian Maihöfner
Jan 11, 2007·Survey of Ophthalmology·K RamaeshB Dhillon
Feb 13, 2013·Pain Research and Treatment·Joel S Goldberg

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