Congenital adrenal hyperplasia complicated by central precocious puberty: linear growth during infancy and treatment with gonadotropin-releasing hormone analog

Metabolism: Clinical and Experimental
A T SolimanM Asfour

Abstract

Some children with congenital adrenal hyperplasia (CAH) develop true precocious puberty with early maturation of the hypothalamic-pituitary-gonadal axis. We have seen six such children who had the diagnosis of CAH with late initiation of corticosteroid treatment and/or poor compliance who developed central precocious puberty (CPP). These patients were treated with standard-dose hydrocortisone and fludrocortisone. Administration of depot leuprorelin (3.75 mg subcutaneously every 28 days) for 2 years or longer was effective in arresting the manifestations of puberty, decelerating the pretreatment growth velocity ([GV] 10.8 +/- 1.5 v3.65 +/- 0.95 cm/yr), increasing the predicted adult height ([PAHT] 147.5 +/- 7.8 v 153.4 +/- 8.3 cm), and decreasing the bone age to statural age ratio (1.26 +/- 0.13 v 1.16 +/- 0.09). Analysis of auxanological data during the first 2 years of life showed that linear growth was significantly accelerated and bone age was advanced in patients who developed CPP compared with 11 age-matched patients. It appears that proper glucocorticoid replacement to achieve adequate control of hyperandrogenemia during early life might prevent development of CPP in these patients. Gonadotropin-releasing hormone agonist ...Continue Reading

References

Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R T KirklandG W Clayton
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S L Kaplan, M M Grumbach
Nov 1, 1989·Archives of Disease in Childhood·M C YoungI A Hughes
Sep 1, 1989·The Journal of Clinical Endocrinology and Metabolism·P M MarthaR M Blizzard
Nov 1, 1988·Archives of Disease in Childhood·I A Hughes
Nov 1, 1987·European Journal of Pediatrics·J P BourguignonC Ernould
Jul 1, 1974·The Journal of Pediatrics·C G BrookG Mürset
Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
Apr 1, 1984·Molecular and Cellular Endocrinology·Y TakahashiR Rappaport
Jun 1, 1995·Journal of Paediatrics and Child Health·Y J LimG L Warne

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Citations

Jan 31, 2006·Indian Journal of Pediatrics·Justin J Brown, Garry L Warne
Mar 5, 2002·Clinical Endocrinology·Carl-Joachim PartschWolfgang G Sippell
Jul 24, 2010·International Journal of Pediatric Endocrinology·Karen J LoechnerAli S Calikoglu
Feb 15, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sherry Lynn Franklin, Mitchell E Geffner
Sep 2, 2004·Paediatric Drugs·Franco Antoniazzi, Giorgio Zamboni
Oct 23, 2012·Indian Journal of Endocrinology and Metabolism·Ashraf T Soliman, Vincenzo De Sanctis
Aug 21, 2013·Indian Journal of Endocrinology and Metabolism·Mahdi KamounMohamed Abid
Apr 20, 2005·Annals of the New York Academy of Sciences·Maria I New
Jun 16, 2015·The Journal of Pediatrics·Erica A Eugster
May 4, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Grete TeilmannJorma Toppari
Feb 23, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Carla BizzarriMarco Cappa
Jun 17, 2000·Endocrine Reviews·P C White, P W Speiser
Jun 5, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Danielle NelsonDavid Stephure
Aug 5, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Anurag BajpaiP S N Menon
Feb 28, 2020·Journal of the Endocrine Society·Robert A SwendimanMaria G Vogiatzi
Apr 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francesco MassartGiuseppe Saggese
Aug 12, 2018·Indian Journal of Pediatrics·Ankita MaheshwariAnuradha Khadilkar
Oct 24, 2019·Indian Journal of Endocrinology and Metabolism·Adnan Al ShaikhAshraf T Soliman
Mar 18, 2006·Arquivos brasileiros de endocrinologia e metabologia·Sofia H V Lemos-MariniAndréa T Maciel-Guerra

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