PMID: 2657709May 1, 1989Paper

Congenital cystic hygroma of the neck diagnosed prenatally: outcome with normal and abnormal karyotype

Prenatal Diagnosis
J S AbramowiczD L Levy


Twenty-two cases of cystic hygromas were diagnosed prenatally at Eastern Virginia Medical School and followed through the neonatal period. Our series was combined with 131 cases which have been described in the literature. Karyotypes were obtained in 110 fetuses and 80 (72.7 per cent) were abnormal. Fifty-one were not terminated: 30 with abnormal and 21 with normal karyotypes. There were no neonatal survivors in the group with abnormal karyotypes. There were five survivors in the 21 with normal karyotypes but only 2/21 without severe medical complications. Combining our series with those previously reported in the literature would suggest only a 2-3 per cent rate of intact survivors when fetal cystic hygromas are diagnosed in utero. This information should be helpful when counselling patients whose pregnancies carry this diagnosis.


Oct 1, 1979·Journal of Clinical Ultrasound : JCU·A H AdamA A Gibson
Jul 1, 1985·American Journal of Medical Genetics·B R ElejaldeJ Leno
Feb 1, 1988·Prenatal Diagnosis·M ZeituneR M Goodman
Feb 1, 1986·American Journal of Obstetrics and Gynecology·A S GardenH A Gardner
Mar 1, 1986·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·M R RahmaniT P Connor
Mar 1, 1987·Radiology·S ShethR C Sanders
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·T LyngbyeJ G Klebe
Oct 1, 1985·The British Journal of Radiology·Y NakazatoR E Falk
May 1, 1985·Prenatal Diagnosis·C MarcheseA Carbonara
Jun 1, 1985·Journal of Clinical Ultrasound : JCU·J M PearceS Campbell
Apr 1, 1974·Journal of Pediatric Surgery· Trán-Ngoc-Ninh, Trán-Xuân-Ninh
Apr 1, 1980·American Journal of Obstetrics and Gynecology·F D FrigolettoH J Finberg
Sep 1, 1984·Prenatal Diagnosis·D H RedfordM E Jamieson
Sep 1, 1984·Prenatal Diagnosis·B DallapiccolaG Villani
Jul 1, 1984·Ultrasound in Medicine & Biology·A KurjakB Rajhvajn
Apr 1, 1983·Journal of Clinical Ultrasound : JCU·U NicoliniG Pardi
Nov 1, 1983·Clinical Genetics·F GreenbergD H Ledbetter
Jan 1, 1984·Human Pathology·J ByrneJ Wigger
Jan 1, 1984·Acta Obstetricia Et Gynecologica Scandinavica·B Gustavii, H Edvall
May 1, 1983·American Journal of Medical Genetics·J M GrahamT H Shepard
Oct 6, 1983·The New England Journal of Medicine·F A ChervenakM J Mahoney
Jul 1, 1982·American Journal of Medical Genetics·F S CowchockD C Lesnick
Sep 1, 1981·American Journal of Clinical Pathology·M BerantS Grunstein
Oct 15, 1980·American Journal of Obstetrics and Gynecology·W F O'BrienD G Bair
Nov 1, 1980·American Journal of Obstetrics and Gynecology·R E SabbaghaA B Gerbie
Jul 1, 1964·British Journal of Plastic Surgery·I W BROOMHEAD
Jan 1, 1951·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·G KNORR


Mar 13, 2001·The Journal of Maternal-fetal Medicine·K E TeagueR B Gherman
Jul 13, 2002·Journal of Clinical Ultrasound : JCU·Norbert GritzmannThomas Rettenbacher
May 1, 1995·Obstetrics and Gynecology·M C McCoyD K Nakayama
May 28, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jonathan A PerkinsEunice Y Chen
Dec 1, 1996·Obstetrics and Gynecology·C G BrumfieldP Cosper
Jan 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P DescampsG Body
Aug 11, 2004·Southern Medical Journal·Mathias B Forrester, Ruth D Merz
Feb 1, 1992·The Australian & New Zealand Journal of Obstetrics & Gynaecology·N G Anderson, J C Kennedy
Mar 1, 1991·Journal of Medical Genetics·A CockwellP Jacobs
Jan 1, 1991·Journal of Perinatal Medicine·T SakaguchiK Ueda
Jan 1, 1991·Journal of Perinatal Medicine·S DrosteL A Mack
Jan 1, 1992·Journal of Perinatal Medicine·W H Sepúlveda, I Ciuffardi
Sep 1, 1991·The British Journal of Radiology·A M MacLeod, J M McHugo
May 1, 1994·American Journal of Obstetrics and Gynecology·P M TraufferR J Wapner
Jan 1, 1993·American Journal of Obstetrics and Gynecology·M P JohnsonM I Evans
Dec 15, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H A TanriverdiW Schmidt
Apr 1, 1996·Journal of Pediatric Surgery·R FisherE Dykes
Mar 1, 1994·Pediatric Pathology·H J Carson, J B Taxy
Nov 10, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Robert Bendon, Alexander Asamoah
Aug 2, 2005·Obstetrics and Gynecology·Fergal D MaloneFASTER Trial Research Consortium
Mar 1, 1990·Prenatal Diagnosis·Y TannirandornC H Rodeck
Feb 1, 1990·Prenatal Diagnosis·B N ChodirkerC R Greenberg
Feb 1, 1995·Prenatal Diagnosis·D CostaA Fortuny
Feb 1, 1992·Prenatal Diagnosis·Y VilleM Lelorc'h
Jun 1, 1991·Prenatal Diagnosis·H S BernsteinM S Golbus
Jun 1, 1990·Prenatal Diagnosis·C BaccichettiA Marini
Feb 15, 1992·American Journal of Medical Genetics·I Lorda-SanchezA Schinzel
Jun 15, 1991·American Journal of Medical Genetics·A E DonnenfeldR J Librizzi
Apr 1, 1996·Pediatric Annals·J S Abramowicz, R Jaffe
Jan 1, 1996·Acta geneticae medicae et gemellologiae·W Malinowski, I Biskup
Oct 8, 2020·American Journal of Medical Genetics. Part a·Ariel T LevyHuda B Al-Kouatly

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Related Papers

The New England Journal of Medicine
F A ChervenakM J Mahoney
Prenatal Diagnosis
H S BernsteinM S Golbus
European Journal of Obstetrics, Gynecology, and Reproductive Biology
U GembruchH J Födisch
American Journal of Obstetrics and Gynecology
M P JohnsonM I Evans
© 2021 Meta ULC. All rights reserved