Congenital cytomegalovirus infection: epidemiology and treatment

Advances in Experimental Medicine and Biology
Richard J Whitley

Abstract

Congenital CMV infection remains a major problem worldwide. Current therapeutic efforts with ganciclovir have been limited to babies with extensive disease. The potential utility for children with less severe disease remains to be determined. Hopefully, the availability of newer compounds with an improved safety profile that will soon enter clinical trials (GW1263) provides hope that treatment for children with congenital CMV can lead to enhanced efficacy. Similar to our understanding of the treatment of congenital Toxoplasma gondii infections, long-term therapy, even up to a year or longer may be required. Ideally, the best approach would be the development of an efficacious vaccine. Regardless, current clinical efforts define a new era for the treatment of congenital infections.

Citations

Nov 30, 2004·Expert Review of Anti-infective Therapy·Wivine BurnyArnaud Marchant
Jul 20, 2005·Expert Review of Vaccines·Mark R Schleiss, Thomas C Heineman
Jul 25, 2009·Expert Review of Vaccines·Wolfgang Herr, Bodo Plachter
Jul 20, 2010·Immunotherapy·Raymund R Razonable
Sep 19, 2015·Xenotransplantation·Joachim Denner
Aug 10, 2019·Frontiers in Genetics·Efe SezginCheryl A Winkler
Jul 13, 2006·European Journal of Pediatrics·Ranjit I KylatElizabeth Lee Ford-Jones
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naeem KhanPaul A H Moss
Aug 30, 2008·Annals of Tropical Paediatrics·S BasuS Basu
Nov 22, 2013·Immunology·Nabila Jabrane-Ferrat, Johan Siewiera
Aug 28, 2007·Developmental Medicine and Child Neurology·Dorota Dunin-WasowiczBogumila Milewska-Bobula
Sep 12, 2013·Clinical & Developmental Immunology·Mark R Schleiss
Aug 2, 2014·Journal of Endocrinological Investigation·Paolo CavarzereFranco Antoniazzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Pediatrics
David W KimberlinNational Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Archives françaises de pédiatrie
J TricoireC Régnier
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
H GuimarãesN Teixeira Santos
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Jin-Tao HuTao Bo
© 2022 Meta ULC. All rights reserved