PMID: 11931729Apr 5, 2002Paper

Congenital Cytomegalovirus Infection

Current Treatment Options in Neurology
J F BaleSusan J. Petheram

Abstract

Intrauterine infection with cytomegalovirus (CMV), a betaherpesvirus, remains the most frequent congenital virus infection in many regions of the world. Although most CMV-infected newborns lack signs of CMV infection, approximately 10% have signs that can consist of low birth weight, jaundice, hepatosplenomegaly, skin rash, microcephaly, and chorioretinitis. Neonates with signs of CMV infection at birth have high rates of audiologic and neurodevelopmental sequelae. Although postnatal therapy with ganciclovir transiently reduces virus shedding and may lessen the audiologic consequences of CMV in some infected infants, additional strategies are needed to prevent congenital CMV disease and to improve the neurodevelopmental prognosis of infants infected with CMV in utero. Some cases of intrauterine infections can be prevented in susceptible women by avoiding contact with the urine or saliva of young children who may be shedding CMV. Vaccines against CMV remain in the experimental stages of development. Termination of pregnancy can be offered to women whose infants have evidence of intrauterine CMV infection and sonographic signs of central nervous system damage. Infants who survive symptomatic intrauterine infections have high rate...Continue Reading

References

Oct 1, 1990·The Pediatric Infectious Disease Journal·J R HockerG P Rabalais
May 29, 1986·The New England Journal of Medicine·R F PassG A Cloud
Aug 19, 1982·The New England Journal of Medicine·R F PassD W Reynolds
Mar 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S IstasJ A Stewart
Mar 1, 1996·The Journal of Pediatrics·J F BaleJ R Murph
Sep 9, 1999·The Journal of Infectious Diseases·R F PassR L Burke
Mar 7, 2000·Intervirology·T LazzarottoM P Landini
Jul 13, 2000·The Journal of Pediatrics·T LazzarottoM P Landini
Aug 19, 2000·The Journal of Infectious Diseases·J F BaleS J Petheram
Mar 10, 2001·The Journal of Pediatrics·D E NoyolaUNKNOWN Houston Congenital CMV Longitudinal Study Group
Apr 13, 2001·Medicinal Research Reviews·A MartinezC Perez
May 3, 2001·The New England Journal of Medicine·S B BoppanaW J Britt

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Citations

Apr 27, 2013·Maternal and Child Health Journal·Rosemary ThackerayKatherine Chipman
Jun 27, 2008·Current Treatment Options in Neurology·Mark R Schleiss
Feb 5, 2003·Journal of Virological Methods·Mark R SchleissDavid I Bernstein
Oct 1, 2003·Antiviral Research·Fernando J BravoDavid I Bernstein
Oct 13, 2009·The Pediatric Infectious Disease Journal·K Yeon ChoiMark R Schleiss
Nov 26, 2010·The Journal of Clinical Investigation·Mark R Schleiss
Mar 14, 2007·Virology Journal·Nigel K WoolfFred J Koehrn
Dec 3, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Na TangFang He
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Jul 20, 2005·Expert Review of Vaccines·Mark R Schleiss, Thomas C Heineman
Nov 30, 2010·Infectious Diseases in Obstetrics and Gynecology·Meaghan A LeddyJay Schulkin
Nov 23, 2010·Expert Review of Vaccines·Heungsup Sung, Mark R Schleiss
Jun 8, 2017·Frontiers in Microbiology·Lucas M StangherlinMaria C C da Silva
Oct 16, 2004·Expert Review of Anti-infective Therapy·Mark R Schleiss, Michael A McVoy
Feb 10, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey R DorfmanPenny L Moore
Aug 5, 2004·The Journal of Pediatrics·Jennifer AccardoAlexander H Hoon
Jul 2, 2021·Antiviral Research·Andrea J ParsonsDomenico Tortorella

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