PMID: 7336165Aug 1, 1981Paper

Congenital deficiency of cyclo-oxygenase in a woman with generalized atherosclerosis

Scandinavian Journal of Haematology
Z BodaK Rak

Abstract

The case of a 52-year-old woman with congenital cyclo-oxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally while that induced by calcium ionophore was normal. No malondialdehyde formation could be detected in her platelet-rich-plasma. The life-long deficiency of cyclo-oxygenase had not protected her from progressive vascular disease. This case suggests that the chronic intake of large doses of aspirin cannot prevent arterial disorders.

References

Apr 2, 1977·Lancet·H J Weiss, B A Lages
May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Jul 13, 1978·The New England Journal of Medicine·UNKNOWN Canadian Cooperative Study Group
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C MalmstenB Samuelsson
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jun 19, 1975·The New England Journal of Medicine·M J StuartF A Oski
Apr 26, 1980·Lancet·F I ParetiG Galli

❮ Previous
Next ❯

Citations

Jun 26, 2020·Platelets·Verónica Palma-BarquerosJosé Rivera
Feb 1, 1984·Scandinavian Journal of Haematology·K NakanishiA Hattori
Jan 1, 1996·Critical Reviews in Oncology/hematology·I Fuse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.