Congenital diaphragmatic hernia and retinoids: searching for an etiology

Pediatric Surgery International
Sandra MontedonicoPrem Puri


Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids and the implications of retinoids in the development of the diaphragm and lung. Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH.


Aug 20, 2009·Pediatric Surgery International·Hideaki SatoPrem Puri
Jan 5, 2012·Orphanet Journal of Rare Diseases·Juan A Tovar
May 7, 2010·Environmental Health Perspectives·Mark D Miller, Melanie A Marty
Nov 25, 2011·Molecular Medicine·Cristina Nogueira-SilvaJorge Correia-Pinto
Feb 4, 2014·Pediatric Surgery International·Hiromizu TakahashiPrem Puri
Dec 10, 2015·Pediatric Surgery International·Hiromizu TakahashiPrem Puri
Dec 14, 2011·Journal of Pediatric Surgery·Eric B JelinDoug Miniati
May 5, 2010·Journal of Pediatric Surgery·Elke RuttenstockPrem Puri
Dec 1, 2009·Journal of Pediatric Surgery·Takashi DoiPrem Puri
Dec 17, 2009·Journal of Pediatric Surgery·Takashi Doi, Prem Puri
Apr 3, 2012·Pediatric Pulmonology·D C M VeenmaD Tibboel
Apr 12, 2015·Pediatric Surgery International·Patrícia Pereira-TerraRichard Keijzer
Oct 17, 2014·Pediatric Surgery International·Toshiaki TakahashiPrem Puri
Dec 18, 2014·World Journal of Pediatrics : WJP·María de Lourdes Lemus-VarelaGuillermo Moisés Zúñiga-González
Jun 2, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gulenay Gencosmanoglu TurkmenDilek Uygur
Aug 3, 2016·Pediatric Surgery International·Toshiaki TakahashiPrem Puri
Nov 26, 2010·Journal of Cardiovascular Medicine·Daria CipolloneBruno Marino
Dec 24, 2014·The Analyst·K M MarzecM Baranska


Dec 1, 1992·Teratology·C P TorfsL H Honoré
Oct 1, 1994·Current Problems in Surgery·P Puri
Jul 1, 1993·Archives of Disease in Childhood·Y Sweed, P Puri
Feb 1, 1994·Mechanisms of Development·P DolléPierre Chambon
Jun 16, 1997·The Journal of Comparative Neurology·Douglas W Allan, John J Greer
Dec 13, 1997·Journal of Pediatric Surgery·Michael R HarrisonRoy A Filly
Mar 5, 1998·Mechanisms of Development·Claes BavikD E Ong
Nov 3, 1998·Pediatric Surgery International·D MajorR Cloutier
Mar 6, 1999·Journal of Applied Physiology·John J GreerR P Lemke
Aug 2, 2000·American Journal of Respiratory Cell and Molecular Biology·S McGowanJ M Snyder
Nov 14, 2000·Physiological Genomics·Gloria DeCarlo MassaroR A Chandraratna
Dec 26, 2001·American Journal of Respiratory Cell and Molecular Biology·Matthew HindMalcolm Maden
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Randal P Babiuk, John J Greer
Jan 1, 2003·The Journal of Comparative Neurology·Randal P BabiukJohn J Greer
Jan 21, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gloria DeCarlo MassaroPierre Chambon
Jan 28, 2003·The American Journal of Pathology·Jörg MeyJohn J Greer
Jul 2, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ghenima DiramiDonald Massaro
Nov 14, 2003·The New England Journal of Medicine·Michael R HarrisonCraig T Albanese
Jan 20, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Randal P BabiukJohn J Greer
Jan 24, 2004·The European Respiratory Journal·M Hind, Malcolm Maden
Feb 26, 2004·Paediatric Respiratory Reviews·M Hösgor, D Tibboel
Jul 31, 2004·Seminars in Perinatology·Felicia A Ivascu, Ronald B Hirschl
Sep 8, 2004·Current Topics in Developmental Biology·Malcolm Maden
Nov 15, 2005·Pediatric Surgery International·Sandra MontedonicoPrem Puri
Dec 7, 2005·Pediatric Surgery International·A MortellPrem Puri
Mar 29, 2006·Journal of Pediatric Surgery·Kevin P LallyCongenital Diaphragmatic Hernia Study Group
May 12, 2006·Journal of Neurobiology·Rune Blomhoff, Heidi Kiil Blomhoff
Jan 5, 2007·Pediatric Surgery International·Nana NakazawaPrem Puri
Feb 3, 2007·Journal of Pediatric Surgery·Nana NakazawaPrem Puri
Aug 21, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·B Rhiannon NobleJohn J Greer

Related Concepts

Metabolic Process, Cellular
Pathogenic Aspects
Entire Diaphragm
Signal Transduction Pathways
Respiratory Failure
Diaphragmatic Hernia

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