Congenital dilatation of the common bile duct and pancreaticobiliary maljunction: clinical implications.

Langenbeck's Archives of Surgery
Wataru Kimura

Abstract

CLINICAL CONDITIONS AND DIAGNOSIS: Congenital dilatation of the common bile duct is a disease in which the extrahepatic bile duct, or both the extra and intrahepatic bile ducts, is dilated in various ways. Pancreaticobiliary maljunction is a disease in which the pancreatic duct meets the bile duct outside of the duodenal wall beyond the sphincter Oddi. Recently, these diseases have been thought to be closely related to each other but to be different malformations. Biliary tract carcinoma, especially bile duct carcinoma, is found in about 30% of patients with congenital dilatation of the bile duct. The concomitance of bile and pancreatic juice and their stasis in the biliary tract induce cellular proliferation and reproduction and stimulate genetic alterations in biliary epithelium, which may play an important role in carcinogenesis of the bile duct. Endoscopic retrograde cholangiopancreatography is useful for examining pancreaticobiliary maljunction. The operation is dilated bile duct resection and hepaticojejunostomy, which ensure that pancreatic juice and bile do not mix in the bile duct. Gallbladder carcinoma develops in more than 90% of pancreaticobiliary maljunction without bile duct dilatation.

Citations

Oct 1, 2013·Journal of Pediatric Surgery·Yao ZhangShu-Cheng Zhang
May 9, 2012·Radiologic Clinics of North America·Lauren F Alexander
Dec 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Terumi KamisawaTsuneo Sasaki
Nov 5, 2015·Journal of Robotic Surgery·Takeshi NaitohMichiaki Unno
Oct 21, 2009·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Rajeev DhuparT Clark Gamblin
Apr 11, 2020·International Journal of Cancer. Journal International Du Cancer·Emma E McGee, Jill Koshiol
Jul 26, 2019·World Journal of Gastroenterology : WJG·George N BaisonRichard A Kozarek
Nov 9, 2021·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Fei LiuJixiao Zeng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.