PMID: 1198065Nov 1, 1975Paper

Congenital dyserythropoietic anaemia with peculiar nuclear abnormality

Scandinavian Journal of Haematology
S WeissM Dialdetti

Abstract

A patient with clinical and haematological findings compatible with congenital dyserythropoietic anaemia (CDA) most porbably type II is described. In contradistinction to previous observations, electron microscope examination of the erythroid cells in the bone marrow showed the concomitant appearance of nuclei at different maturation stages in a single cell. In addition, a marked tendency toward multinuclearity of the megakaryocytes was found. The mature erythroblasts showed an increased uptake of 3H-thymidine less than is normally found in these cells. Thes findings suggest an impairment in RNA and DNA synthesis.

References

Jun 14, 1970·Journal of Molecular Biology·M DjaldettiR A Rifkind
Sep 1, 1972·Annals of Internal Medicine·R W EnquistD E Dillon
Jul 1, 1972·British Journal of Haematology·S M Lewis, R L Verwilghen
Jul 1, 1972·British Journal of Haematology·S M LewisC S Pitcher
Jul 1, 1972·British Journal of Haematology·R GoudsmitE Reynierse
Jul 1, 1972·Journal of Clinical Pathology·M BrightT E Parry

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