Congenital familial subglottic stenosis: a case series and review of literature

International Journal of Pediatric Otorhinolaryngology
J ManickavasagamM S Thevasagayam

Abstract

Subglottic stenosis is a narrowing of the endolarynx and maybe classified as congenital (primary) or acquired (secondary). Congenital stenosis maybe caused by a small cricoid cartilage, thick submucosa or other laryngeal abnormalities and remains a well-known cause of stridor in infancy. It occurs sporadically and familial occurrence is rare. Our case series identifies three children with congenital subglottic stenosis born to consanguineous parents. Congenital subglottic stenosis in siblings of unrelated parents has been previously reported, but not in consanguineous parents indicating a strong genetic link. We recommend further genetic research to assess the mode of possible heritage in this disease.

References

Jun 1, 1979·The Laryngoscope·G F TuckerL D Holinger
Nov 1, 1996·International Journal of Pediatric Otorhinolaryngology·L RuanR H Lazar
Oct 21, 1998·International Journal of Pediatric Otorhinolaryngology·M PizzutoL Brodsky
Jan 19, 2000·Otolaryngologic Clinics of North America·R T Cotton
Jun 11, 2004·Acta Paediatrica·O LinnaL Pajunen

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Citations

Aug 25, 2018·Clinical and Experimental Otorhinolaryngology·Filiz UzumcugilBilge Celebioglu

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