PMID: 10513694Oct 8, 1999

Congenital fiber type disproportion: severe form with marked improvement

Pediatric Neurology
M TsujiH Hattori

Abstract

A 30-month-old male exhibited marked hypotonia at birth accompanied by respiratory distress necessitating ventilator support. He subsequently demonstrated marked improvement in muscle power. He became independent of the respirator at 21 days of age and was able to sit without support at 11 months and walked alone at 24 months. Histopathologic analysis of the quadriceps femoris muscle confirmed the diagnosis of congenital fiber type of disproportion at 11 months of age. No other studies have described a patient with a severe neonatal form of congenital fiber type of disproportion who demonstrated such clear improvement. Physicians should be aware of this possibility when they interact with such patients and their families.

References

Sep 18, 2003·Brain & Development·Asuri N Prasad, Chitra Prasad
Oct 25, 2003·Journal of Neuropathology and Experimental Neurology·Nigel F Clarke, Kathryn N North

Citations

Oct 1, 1979·Archives of Disease in Childhood·N P CavanaghP McMeniman
Jun 1, 1980·Journal of the Neurological Sciences·R R ClancyJ W Oehlert
Feb 1, 1994·Muscle & Nerve·J B Bodensteiner
Sep 1, 1996·Brain & Development·C Akiyama, I Nonaka

Related Concepts

Autosomal Recessive Centronuclear Myopathy
Respiratory Complication
Congenital Fiber Type Disproportion
MPFD gene
Congenital Myopathy (Disorder)
Severity of Illness Index
Respiratory Distress Syndrome, Newborn
Byzanthine Arch Palate
Muscle
Disproportion NOS, Unspecified

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