Congenital fibroblastic connective tissue nevi: Unusual and misleading presentations in three infantile cases

Pediatric Dermatology
Jebrane BouaoudRoman H Khonsari

Abstract

Fibroblastic connective tissue nevi (FCTN) are benign skin conditions characterized by bland spindle cells infiltrating the reticular dermis and the upper subcutis with preservation of adnexal structures. A subset of FCTN expresses CD34, which may cause difficulties in the differential diagnosis, in particular with dermatofibrosarcoma (DFSP). We aim to study clinical and histological main features of congenital FCTN to better understand their heterogeneity. We present 3 cases of congenital FCTN with misleading pseudo-tumoral presentations and compare them with published cases in literature. We provide a diagnostic algorithm for congenital neonatal connective tissue tumors. Clinically, FCTN mostly present as well-limited and nontender plaques or nodules mainly located in the neck and face areas or in the trunk. Histologically, FCTN are composed of irregularly distributed fascicles of bland spindled cells and are defined by a list of fundamental features: (i) no atypia, pleomorphism, or mitotic activity; (ii) skin appendages entrapped but unaffected; (iii) no evidence for malignancy. In most cases CD34 is positive, but in some cases, cells can express SMA or are even CD34- and SMA-. The initial presentation and natural history of...Continue Reading

References

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Sep 26, 2017·European Journal of Dermatology : EJD·Hiromi Higaki-MoriOsamu Yamamoto

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Citations

Aug 31, 2019·Pediatric Dermatology·Marie OhataChikako Nishigori
May 28, 2021·Clinical and Experimental Dermatology·A ShahidW Abdelrahman
Aug 28, 2021·Dermatopathology·Philippe Drabent, Sylvie Fraitag

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