Congenital heart block related to maternal autoantibodies: descriptive analysis of a series of 18 cases from a single center

Clinical Rheumatology
Pamela I DotiGerard Espinosa

Abstract

The objective of this study was to describe the clinical and immunological characteristics of maternal autoimmune-mediated fetal congenital heart block (CHB) in a cohort of pregnant women from an autoimmune disease pregnancy clinic. This is a retrospective observational study of all women presenting with CHB in our autoimmune disease pregnancy clinic from January 1997 to December 2014. In addition, perinatal outcome is also described. Fourteen patients accounting for 18 fetuses with CHB were identified. The median age was 32.5 years (range, 22-40). Seven (50 %) patients had Sjögren's syndrome, and the remaining seven were asymptomatic carriers of autoantibodies. All patients had anti-Ro/SSA antibodies, and 11/13 (85 %) had anti-La/SSB antibodies. The median gestational age at the time of CHB was 22 weeks (range 18-28). Complete third degree CHB was detected in 12 (67 %). Seven cases of CHB were treated with dexamethasone, two with ritodrine, and one with the association of dexamethasone, ritodrine, and terbutaline. In 9 (50 %) cases that presented with, or developed, very poor prognosis factors, such as a ventricular rate below 50-55 bpm and/or the presence of fetal hydrops, parents opted for the termination of pregnancy, after...Continue Reading

References

Nov 1, 2002·Archives of Gynecology and Obstetrics·H MatsushitaK Tanaka
Jun 1, 2011·The American Journal of Cardiology·Debra L DaveyAnji T Yetman
Oct 12, 2011·Circulation·Håkan EliassonUNKNOWN Fetal Working Group of the European Association of Pediatric Cardiology
Oct 16, 2012·American Journal of Obstetrics and Gynecology·Robert D TunksPiers C A Barker
Sep 25, 2014·The American Journal of Cardiology·Gabriel AltitAnne Fournier
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Aug 19, 2015·Autoimmunity Reviews·Kateri LevesqueUNKNOWN Group of collaborators

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Citations

Apr 14, 2020·Prenatal Diagnosis·Meghana A LimayeShilpi S Mehta-Lee
May 26, 2017·Current Cardiology Reports·A L P CaforioS Iliceto
Oct 13, 2017·Journal of Clinical Ultrasound : JCU·Fuanglada TongprasertTheera Tongsong
Nov 12, 2018·Journal of Gynecology Obstetrics and Human Reproduction·Adélie MichauAlexandra Benachi
May 18, 2021·Frontiers in Cardiovascular Medicine·Hongyu LiaoYifei Li

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